DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ND5 and ND5

DIOPT Version :9

Sequence 1:	YP_009047273.1	Gene:	ND5 / 19893549	FlyBaseID:	FBgn0013684	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	YP_665639.1	Gene:	ND5 / 26202	RGDID:	620560	Length:	609	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	209/588 - (35%)
Similarity:	328/588 - (55%)	Gaps:	47/588 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SISFVNLISMSLSCFLLSLYFLLNDMIYFIEWELVSLNSMSIVMTFLFDWMSLLFMSFVLMISSL 67
            ||.|    |..||...|.|:|..|.......|..:::||:.:.|:|..|:.|:||:|..|.::..
  Rat    39 SIKF----SFLLSLLPLLLFFHHNTEYMITNWHWLTINSIKLTMSFKIDYFSILFLSVALFVTWS 99

  Fly    68 VIFYSKEYMMNDNHINRFIMLVLMFVLSMMLLIISPNLISILLGWDGLGLVSYCLVIYFQNIKSY 132
            ::.:|..||.:|.||||||..::||:::|::|..:.||..:.:||:|:|::|:.|:.::......
  Rat   100 IMQFSSWYMHSDPHINRFIKYLMMFLITMLILTSANNLFQLFIGWEGVGIMSFLLIGWWYGRADA 164

  Fly   133 NAGMLTA-LSNRIGDVALLLSIAWM-LNYGSW--NYIFYLEIMQNEFEMLMIGSLVMLAAMTKSA 193
            |...|.| |.||:||:..:|::.|. ||..||  ..||    :.|...::.:..| ::||..|||
  Rat   165 NTAALQAILYNRVGDIGFILAMTWFCLNMNSWELQQIF----LTNTNNLVPLTGL-LIAATGKSA 224

  Fly   194 QIPFSSWLPAAMAAPTPVSALVHSSTLVTAGVYLLIRFNIILS-TSWLGQLMLLLSGLTMFMAGL 257
            |.....|||:||..|||||||:||||:|.||::|:|||:.:.| .|.:...||.|..:|.....:
  Rat   225 QFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLMIRFHPLTSNNSTIMTAMLCLGAITTLFTAI 289

  Fly   258 GANFEFDLKKIIALSTLSQLGLMMSILSMGFLKLAMFHLLTHALFKALLFMCAGAIIHNMNNSQD 322
            .|..:.|:|||:|.||.|||||||..|.:....||..|:.|||.|||:||||:|:|||::|:.||
  Rat   290 CALTQNDIKKIVAFSTSSQLGLMMVTLGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQD 354

  Fly   323 IRLMGGLSIHMPLTSACFNVSNLALCGMPFLAGFYSKDMILEIVSISNVNMFSFFLYYFSTGLTV 387
            ||.||.:...||.||:|..:.:|||.|||||.||||||:|:|.::..|.|.::..:...:|.:|.
  Rat   355 IRKMGNMMKAMPFTSSCLIIGSLALTGMPFLTGFYSKDLIIEAINTCNTNAWALMITLIATSMTA 419

  Fly   388 SYSFRLVYYSMTGDLNCGSLNMLNDESWIMLRGMMGLLIMSIIGGSMLNWLIFPFPYMI-CLPIY 451
            .||.|::|:..........|..:|:.:..::..:..|.:.||:.|.:::..|.|....| .:|.:
  Rat   420 VYSMRIIYFVTMTKPRYSPLITINENNPNLINPIKRLALGSILAGFLISLNIPPTNIQILTMPWH 484

  Fly   452 MKLLTLFVCIVGGLFGYLISLSNLFFLNKSLFM-YNLSTFLGSMWFMPYI-----------STYG 504
            :|:..|.:.|:|  |...:.|:|| .||.|:.. ..||:|..|:.:.|.|           |:|
  Rat   485 LKMTALLITILG--FAIALELNNL-TLNLSMSKPTKLSSFSTSLGYYPPIMHRIIPQKTLNSSY- 545

  Fly   505 MIFYPLNYGQLVVKSFDQGWSEYFGGQHLYQKLSMYSKTLFLMHNNS---LKIYLLLFVFWILIL 566
                     :|.:...|..|.|    :.:.:..|:....|..|.:|.   :|:|.|.|:..|.::
  Rat   546 ---------KLSLNLLDLIWLE----KTIPKSTSITQTQLSKMMSNQKGLIKLYFLSFLITISLI 597

  Fly   567 LIL 569
            .||
  Rat   598 FIL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND5	YP_009047273.1	ND5	1..562	CDD:214444	206/579 (36%)
ND5	YP_665639.1	ND5	1..600	CDD:177170	206/581 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353193
Domainoid	1	1.000	231	1.000	Domainoid score	I2345
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2367
OMA	1	1.010	-	-		QHG46593
OrthoDB	1	1.010	-	-		D365032at33208
OrthoFinder	1	1.000	-	-		FOG0004209
OrthoInspector	1	1.000	-	-		oto97831
orthoMCL	1	0.900	-	-		OOG6_101851
Panther	1	1.100	-	-	LDO	PTHR42829
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2954
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910