DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ND5 and ND5

DIOPT Version :9

Sequence 1:	YP_009047273.1	Gene:	ND5 / 19893549	FlyBaseID:	FBgn0013684	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_006964.1	Gene:	ND5 / 2565703	-ID:		Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	191/578 - (33%)
Similarity:	299/578 - (51%)	Gaps:	77/578 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MSLSCFLLSLYFLLNDM-----------IYFIEWELVSLNSMSIVMTFLFDWMSLLFMSFVLMIS 65
            |::|.||:...|.:..:           |:|:||:.:||.       |.|.:.|:||...:.:::
Worm     1 MNISIFLIGFVFFMGGISVWLMPTFKLGIFFLEWDFLSLK-------FNFYFNSILFSFILFLVT 58

  Fly    66 SLVIFYSKEYMMNDNHINRFIMLVLMFVLSMMLLIISPNLISILLGWDGLGLVSYCLVIYFQNIK 130
            ..|:.:|..|:.::.:.|.:..::|:||.||..|..|.::.::||.||.||:.|:.||:::.|..
Worm    59 FSVLVFSTYYLNSELNFNYYYFVLLIFVGSMFSLNFSNSIFTMLLSWDLLGISSFFLVLFYNNWD 123

  Fly   131 SYNAGMLTALSNRIGDVALLLSIAWMLNYGSWNYIFYLEIMQNEFEMLMIGSLVMLAAMTKSAQI 195
            |.:..|.|||:||:||..:.:.....:..|   |.|....|.:.:..|    |::|.|.|||||.
Worm   124 SCSGAMNTALTNRLGDYFMFVFFGLSVFSG---YYFLSFSMFSSYMSL----LLLLTAFTKSAQF 181

  Fly   196 PFSSWLPAAMAAPTPVSALVHSSTLVTAGVYLLIRFNIILSTSWLGQLMLLLSGLTMFMAGLGAN 260
            |||||||.||:||||||:|||||||||||:.||:.||.::........:|::...|||.:.|.:.
Worm   182 PFSSWLPKAMSAPTPVSSLVHSSTLVTAGLILLMNFNNLVMQKDFISFVLIIGLFTMFFSSLASL 246

  Fly   261 FEFDLKKIIALSTLSQLGLMMSILSMGFLKLAMFHLLTHALFKALLFMCAGAIIHNMNNSQDIR- 324
            .|.||||::|||||||:|..|..|.:|...::..||::|||||:.|||..|.|||.....||.|
Worm   247 VEEDLKKVVALSTLSQMGFSMVTLGLGLSFISFIHLVSHALFKSCLFMQVGYIIHCSFGQQDGRN 311

  Fly   325 ------LMGGLSIHMPLTSACFNVSNLALCGMPFLAGFYSKDMILEIVSISNVNMFSFFLYYFST 383
                  |...:.:.|.:|..|       |||:.|.:|..|||.|||:...:|..||...:::.|.
Worm   312 YSNNGNLPNFIQLQMLVTLFC-------LCGLIFSSGAVSKDFILELFFSNNYMMFFSLMFFVSV 369

  Fly   384 GLTVSYSFRLVYYSMTGDLNCGSLNMLNDESWIMLRGMMGLLIMSIIGGSMLNWLIFPFPYMICL 448
            .||..||||| :.|.....|    .::|..|..:....:.|::: |...|.|.|:.|..
Worm   370 FLTFGYSFRL-WKSFFLSFN----KVMNHYSSTVFMNFLSLVLV-IFSISFLWWMNFNL------ 422

  Fly   449 PIYMKLLTLFVCIVGGLFGYLISLSNLFFLN----KSLFMYNLSTFLGSMWFMPYI---STYGMI 506
               :.:.:||:.:  ..||.|:.|..:.||:    |.||...:..||     :.|:   |.|.|
Worm   423 ---LNIPSLFLYV--DFFGPLVFLFMMIFLSFLILKMLFKELMYKFL-----VDYLAKNSIYKM- 476

  Fly   507 FYPLNYGQLVVKSFDQGWSEYFGGQHLYQKLSMYSKTLFLMHNNSLKIYLLLFVFWIL 564
             ..|.:..|.:.:.:.      .|..|:....|: |..:|...|...:.:|:|:|:::
Worm   477 -KNLKFMDLFLNNINS------KGYTLFLSSGMF-KNYYLKSLNFNSVVVLIFIFFMI 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND5	YP_009047273.1	ND5	1..562	CDD:214444	190/574 (33%)
ND5	NP_006964.1	ND5	1..526	CDD:177158	184/549 (34%)
ND5	NP_006964.1	Proton_antipo_M	95..368	CDD:278775	118/279 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I1821
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1989
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46593
OrthoDB	1	1.010	-	-		D365032at33208
OrthoFinder	1	1.000	-	-		FOG0004209
OrthoInspector	1	1.000	-	-		oto18879
orthoMCL	1	0.900	-	-		OOG6_101851
Panther	1	1.100	-	-	LDO	PTHR42829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2693
SonicParanoid	1	1.000	-	-		X2954
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010