DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ND5 and ND5

DIOPT Version :9

Sequence 1:	YP_009047273.1	Gene:	ND5 / 19893549	FlyBaseID:	FBgn0013684	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_059341.1	Gene:	ND5 / 140535	ZFINID:	ZDB-GENE-011205-12	Length:	606	Species:	Danio rerio

Alignment Length:	588	Identity:	201/588 - (34%)
Similarity:	334/588 - (56%)	Gaps:	44/588 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NLISMSLSCFLLSLYFLLNDMIY------FIEWELVSLNSMSIVMTFLFDWMSLLFMSFVLMISS 66
            |.:.:|   ||:|| ..|..|:|      .:.|..::..:.::.::|.||:.|:.|.|..|.|:.
Zfish    38 NAVHVS---FLISL-IPLTMMLYKESDHVVMCWSWMNTQAFNVDLSFKFDYYSVTFTSIALFITW 98

  Fly    67 LVIFYSKEYMMNDNHINRFIMLVLMFVLSMMLLIISPNLISILLGWDGLGLVSYCLV-IYFQNIK 130
            .::.::..||.:......|...:|:|::||::|:.:.||..:.:||:|:|::|:.|: .:|...:
Zfish    99 SILEFASWYMASYPQKELFYKYLLLFLMSMIILVTANNLFQLFIGWEGVGIMSFLLIGWWFGRTE 163

  Fly   131 SYNAGMLTALSNRIGDVALLLSIAWMLNY-GSWNYIFYLEIMQNEFEMLMIGSLVMLAAMTKSAQ 194
            :..|.:...:.||:||:..:|::|||..| .||: |..:.|:..:|:|.:....:::||..||||
Zfish   164 ANTASLQAVIYNRMGDIGFILTLAWMAMYLNSWD-IQQIFILSKDFDMTIPQIGLIIAATGKSAQ 227

  Fly   195 IPFSSWLPAAMAAPTPVSALVHSSTLVTAGVYLLIRFNIILSTSWLG-QLMLLLSGLTMFMAGLG 258
            .....|||:||..|||||||:||||:|.||::||||.:.|:.|:.|. .:.|.|..||...|...
Zfish   228 FTLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRLHPIMETNKLAPTICLCLGALTTLFAATC 292

  Fly   259 ANFEFDLKKIIALSTLSQLGLMMSILSMGFLKLAMFHLLTHALFKALLFMCAGAIIHNMNNSQDI 323
            |..:.|:|||:|.||.|||||||..:.:....||.||:.|||.|||:||:|:|||||::||.|||
Zfish   293 ALTQNDIKKIVAFSTSSQLGLMMVAIGLNQPHLAFFHICTHAFFKAMLFLCSGAIIHSLNNEQDI 357

  Fly   324 RLMGGLSIHMPLTSACFNVSNLALCGMPFLAGFYSKDMILEIVSISNVNMFSFFLYYFSTGLTVS 388
            |.|||....:|:|:....:..:||.|.||||||:|||.|||.::.|::|.::..|...:|..|..
Zfish   358 RKMGGTYHTLPMTTNYLTIGKMALMGTPFLAGFFSKDAILEAMTTSHLNAWALTLTLIATSFTAV 422

  Fly   389 YSFRLVYYSMTGDLNCGSLNMLNDESWIMLRGMMGLLIMSIIGGSMLNWLIFPFPY-MICLPIYM 452
            ||||::|....|.....:...: ||:.|....:..|...|||.|.::::.:.|... ::.:|||:
Zfish   423 YSFRMIYLVCLGSPRHKTYETI-DENHIPTNTIQRLAWGSIIAGLIISYTMIPLKTPILTMPIYL 486

  Fly   453 KLLTLFVCIVGGLFGYLIS-LSNLFFLNKSLFMYNLSTFLGSMWFMPYISTYGMIFYPLNY---- 512
            ||..:.|.::|.:.|..|| |:|         ..|.:|..|    :|:..:..:||:|:.:
Zfish   487 KLAAILVTLLGIILGLEISTLAN---------KINKNTTPG----IPFHFSISLIFFPILHRLIP 538

  Fly   513 ------GQLVVKSFDQGWSEYFGGQHLYQKLSMYSKTLFLMHNN--SLKIYLLLFVFWILILLIL 569
                  |:......::.|||.||...:  ..::.:...|:..:.  |:|.||.:|:..|::.:::
Zfish   539 MRKLFMGESAATKIEKSWSELFGPCGI--AFTLMTVATFVKDHRMASIKSYLAVFLTSIILKMMM 601

  Fly   570 LFL 572
            |.|
Zfish   602 LKL 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND5	YP_009047273.1	ND5	1..562	CDD:214444	198/576 (34%)
ND5	NP_059341.1	ND5	1..602	CDD:214428	200/586 (34%)
		Proton_antipo_N	66..112	CDD:279055	10/45 (22%)
		Proton_antipo_M	134..417	CDD:278775	125/285 (44%)
		NADH5_C	423..602	CDD:283988	44/192 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595279
Domainoid	1	1.000	236	1.000	Domainoid score	I2286
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2504
OMA	1	1.010	-	-		QHG46593
OrthoDB	1	1.010	-	-		D365032at33208
OrthoFinder	1	1.000	-	-		FOG0004209
OrthoInspector	1	1.000	-	-		oto40900
orthoMCL	1	0.900	-	-		OOG6_101851
Panther	1	1.100	-	-	LDO	PTHR42829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2693
SonicParanoid	1	1.000	-	-		X2954
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940