DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COX3 and COX3

DIOPT Version :9

Sequence 1:	YP_009047271.1	Gene:	COX3 / 19893540	FlyBaseID:	FBgn0013676	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	YP_003024032.1	Gene:	COX3 / 4514	HGNCID:	7422	Length:	261	Species:	Homo sapiens

Alignment Length:	259	Identity:	169/259 - (65%)
Similarity:	207/259 - (79%)	Gaps:	0/259 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 THSNHPFHLVDYSPWPLTGAIGAMTTVSGMVKWFHQYDISLFVLGNIITILTVYQWWRDVSREGT 67
            ||.:|.:|:|..||||||||:.|:...||:..|||.:.::|.:||.:...||:|||||||:||.|
Human     2 THQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTREST 66

  Fly    68 YQGLHTYAVTIGLRWGMILFILSEVLFFVSFFWAFFHSSLSPAIELGASWPPMGIISFNPFQIPL 132
            |||.||..|..|||:||||||.|||.||..|||||:||||:|..:||..|||.||...||.::||
Human    67 YQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPL 131

  Fly   133 LNTAILLASGVTVTWAHHSLMENNHSQTTQGLFFTVLLGIYFTILQAYEYIEAPFTIADSIYGST 197
            |||::||||||::|||||||||||.:|..|.|..|:|||:|||:|||.||.|:||||:|.|||||
Human   132 LNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGST 196

  Fly   198 FFMATGFHGIHVLIGTTFLLVCLLRHLNNHFSKNHHFGFEAAAWYWHFVDVVWLFLYITIYWWG 261
            ||:||||||:||:||:|||.:|.:|.|..||:..|||||||||||||||||||||||::|||||
Human   197 FFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX3	YP_009047271.1	COX3	4..258	CDD:214439	163/253 (64%)
COX3	YP_003024032.1	COX3	1..261	CDD:177161	169/259 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159698
Domainoid	1	1.000	385	1.000	Domainoid score	I813
eggNOG	1	0.900	-	-		E1_COG1845
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	390	1.000	Inparanoid score	I2005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62397
OrthoDB	1	1.010	-	-		D1304563at2759
OrthoFinder	1	1.000	-	-		FOG0003223
OrthoInspector	1	1.000	-	-		oto90101
orthoMCL	1	0.900	-	-		OOG6_104028
Panther	1	1.100	-	-	LDO	PTHR11403
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R246
SonicParanoid	1	1.000	-	-		X2639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800