DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COX1 and COX1

DIOPT Version :9

Sequence 1:	YP_009047267.1	Gene:	COX1 / 19893533	FlyBaseID:	FBgn0013674	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_009305.1	Gene:	COX1 / 854598	SGDID:	S000007260	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	527	Identity:	310/527 - (58%)
Similarity:	403/527 - (76%)	Gaps:	25/527 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RQWLFSTNHKDIGTLYFIFGAWAGMVGTSLSILIRAELGHPGA--LIGDDQIYNVIVTAHAFIMI 64
            ::||:|||.|||..|||:...::||.||::|::||.||..||:  |.|:.|::||:|..||.:||
Yeast     3 QRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMI 67

  Fly    65 FFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALSLLLVSSMVENGAGTGWTVYPP 129
            ||:|||.:||||||:|:|||:||.|.||||:||::||:||..|..|:.|::||:|||||||||||
Yeast    68 FFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPP 132

  Fly   130 LSAGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGISLDRMPLFVWSVVITALLLL 194
            ||:..||.|.|||||||:|||..|||:|||:|||.|.:|||:.|:::.::||||||:.|||.|||
Yeast   133 LSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLL 197

  Fly   195 LSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQE 259
            ||||||:..|||||.|||.|||||:.:||||||||:|||||||||||||||:||||:|||::|..
Yeast   198 LSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTY 262

  Fly   260 SGKKETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLAT 324
            | ||..||.:.|:|||.:||||||:||:|||:.||:|.||||||||||||||:||||||||||||
Yeast   263 S-KKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLAT 326

  Fly   325 LHGTQLSYSPAILWALGFVFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMA 389
            :||..:..:..:|:|:.|:||||:||||||.|||:|:|:..|||||||.||||||||||:|::.|
Yeast   327 IHGGSIRLATPMLYAIAFLFLFTMGGLTGVALANASLDVAFHDTYYVVGHFHYVLSMGAIFSLFA 391

  Fly   390 GFIHWYPLFTGLTLNNKWLKSHFIIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNIVSTI 454
            |:.:|.|...||..|.|..:..|.::|||.|:.|||.||||:.|||||..|||||:..||.|::|
Yeast   392 GYYYWSPQILGLNYNEKLAQIQFWLIFIGANVIFFPMHFLGINGMPRRIPDYPDAFAGWNYVASI 456

  Fly   455 GSTISLLGILFFFFIIWESL-------VSQRQVIYP-----------IQLN----SSIEWYQNTP 497
            ||.|:.|.:..|.:|:::.|       |:.:.|||.           ..||    ||||:...:|
Yeast   457 GSFIATLSLFLFIYILYDQLVNGLNNKVNNKSVIYNKAPDFVESNTIFNLNTVKSSSIEFLLTSP 521

  Fly   498 PAEHSYS 504
            ||.||::
Yeast   522 PAVHSFN 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX1	YP_009047267.1	COX1	1..511	CDD:177210	310/527 (59%)
COX1	NP_009305.1	Cyt_c_Oxidase_I	9..488	CDD:238833	296/498 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346755
Domainoid	1	1.000	612	1.000	Domainoid score	I19
eggNOG	1	0.900	-	-		E1_COG0843
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I108
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61018
OrthoFinder	1	1.000	-	-		FOG0002409
OrthoInspector	1	1.000	-	-		otm46765
orthoMCL	1	0.900	-	-		OOG6_102770
Panther	1	1.100	-	-	LDO	PTHR10422
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R244
SonicParanoid	1	1.000	-	-		X1600
TreeFam	1	0.960	-	-
	14	13.790