DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COX1 and AI5_ALPHA

DIOPT Version :9

Sequence 1:	YP_009047267.1	Gene:	COX1 / 19893533	FlyBaseID:	FBgn0013674	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_009306.1	Gene:	AI5_ALPHA / 854597	SGDID:	S000007265	Length:	630	Species:	Saccharomyces cerevisiae

Alignment Length:	323	Identity:	214/323 - (66%)
Similarity:	271/323 - (83%)	Gaps:	3/323 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RQWLFSTNHKDIGTLYFIFGAWAGMVGTSLSILIRAELGHPGA--LIGDDQIYNVIVTAHAFIMI 64
            ::||:|||.|||..|||:...::||.||::|::||.||..||:  |.|:.|::||:|..||.:||
Yeast     3 QRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMI 67

  Fly    65 FFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALSLLLVSSMVENGAGTGWTVYPP 129
            ||:|||.:||||||:|:|||:||.|.||||:||::||:||..|..|:.|::||:|||||||||||
Yeast    68 FFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPP 132

  Fly   130 LSAGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGISLDRMPLFVWSVVITALLLL 194
            ||:..||.|.|||||||:|||..|||:|||:|||.|.:|||:.|:::.::||||||:.|||.|||
Yeast   133 LSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLL 197

  Fly   195 LSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQE 259
            ||||||:..|||||.|||.|||||:.:||||||||:|||||||||||||||:||||:|||::|..
Yeast   198 LSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTY 262

  Fly   260 SGKKETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWL 322
            | ||..||.:.|:|||.:||||||:||:|||:.||:|.||||||||||||||:||||||||||
Yeast   263 S-KKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX1	YP_009047267.1	COX1	1..511	CDD:177210	214/323 (66%)
AI5_ALPHA	NP_009306.1	Heme_Cu_Oxidase_I	9..>324	CDD:294196	209/315 (66%)
		COX1	13..>325	CDD:278541	208/313 (66%)
		LAGLIDADG_2	424..601	CDD:281195
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0843
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002409
OrthoInspector	1	1.000	-	-		otm46765
orthoMCL	1	0.900	-	-		OOG6_102770
Panther	1	1.100	-	-	O	PTHR10422
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1600
TreeFam	1	0.960	-	-
	9	8.700