Protein Alignment COX1 and AI4

DIOPT Version :10

• Sequence 1: YP_009047267.1
• Gene: COX1 / 19893533
• FlyBaseID: FBgn0013674
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_009307.2
• Gene: AI4 / 854596
• SGDID: S000007264
• Length: 556
• Species: Saccharomyces cerevisiae
• Alignment Length: 533
• Identity: 195/533 - (36%)
• Similarity: 279/533 - (52%)
• Gaps: 123/533 - (23%)

  Fly     2 RQWLFSTNHKDIGTLYFIFGAWAGMVGTSLSILIRAELGHPGA--LIGDDQIYNVIVTAHAFIMI 64
            ::||:|||.|||..|||:...::||.||::|::||.||..||:  |.|:.|::||:|..||.:||
Yeast     3 QRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMI 67

  Fly    65 FFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALSLLLVSSMVENGAGTGWTVYPP 129
            ||:|||.:||||||:|:|||:||.|.||||:||::||:||..|..|:.|::||:|||||||||||
Yeast    68 FFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPP 132

  Fly   130 LSAGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGISLDRMPLFVWSVVITALLLL 194
            ||:..||.|.|||||||:|||..|||:|||:|||.|.:|||:.|:::.::||||||:.|||.|||
Yeast   133 LSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLL 197

  Fly   195 LSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFG--------- 250
            ||||||:..|||||.|||.|||||:.:||||||||:|||||||.....|::|..:.
Yeast   198 LSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGQTVATIIMLMMYNDMHFSKCWK 262

  Fly   251 ----MISHII-----------------------------------SQESGKKETFGSLGMIYAML 276
                .|::|:                                   |.|:.:|....|:...:...
Yeast   263 LLKKWITNIMSTLFKALFVKMFMSYNNQQDKMMNNTMLKKDNIKRSSETTRKMLNNSMNKKFNQW 327

  Fly   277 AIGLLGFIVWAHHMFTVGMDVDTRAYF-------TSATMIIAVPTGIKIFSWLATLHGTQLSYSP 334
            ..||                :|...||       .|..:.:|:...:       .|...|..:..
Yeast   328 LAGL----------------IDGDGYFGIVSKKYVSLEITVALEDEM-------ALKEIQNKFGG 369

  Fly   335 AILWALGF-VFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLF 398
            :|....|. ...:.:...||::...::|:..:.:|..:| .|:.|       .|:.|....||:
Yeast   370 SIKLRSGVKAIRYRLTNKTGMIKLINAVNGNIRNTKRLV-QFNKV-------CILLGIDFIYPI- 425

  Fly   399 TGLTLNNKWLKSHFIIMFIG-------VNLTFFPQH-----------------FLGLAGMPRRYS 439
             .||.:|.|        |:|       :|.:|...|                 :..:.|....:.
Yeast   426 -KLTKDNSW--------FVGFFDADGTINYSFKNNHPQLTISVTNKYLQDVQEYKNILGGNIYFD 481

  Fly   440 DYPDAYTTWNIVS 452
            ...:.|..|:|.|
Yeast   482 KSQNGYYKWSIQS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COX1	YP_009047267.1	COX1	1..511	CDD:177210	195/533 (37%)
AI4	NP_009307.2	Heme_Cu_Oxidase_I	9..>240	CDD:469701	146/230 (63%)
		LAGLIDADG_1	328..415	CDD:395767	18/117 (15%)
		LAGLIDADG_1	434..526	CDD:395767	10/61 (16%)