DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COX1 and AI4

DIOPT Version :9

Sequence 1:	YP_009047267.1	Gene:	COX1 / 19893533	FlyBaseID:	FBgn0013674	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_009307.2	Gene:	AI4 / 854596	SGDID:	S000007264	Length:	556	Species:	Saccharomyces cerevisiae

Alignment Length:	533	Identity:	195/533 - (36%)
Similarity:	279/533 - (52%)	Gaps:	123/533 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RQWLFSTNHKDIGTLYFIFGAWAGMVGTSLSILIRAELGHPGA--LIGDDQIYNVIVTAHAFIMI 64
            ::||:|||.|||..|||:...::||.||::|::||.||..||:  |.|:.|::||:|..||.:||
Yeast     3 QRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMI 67

  Fly    65 FFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALSLLLVSSMVENGAGTGWTVYPP 129
            ||:|||.:||||||:|:|||:||.|.||||:||::||:||..|..|:.|::||:|||||||||||
Yeast    68 FFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPP 132

  Fly   130 LSAGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGISLDRMPLFVWSVVITALLLL 194
            ||:..||.|.|||||||:|||..|||:|||:|||.|.:|||:.|:::.::||||||:.|||.|||
Yeast   133 LSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLL 197

  Fly   195 LSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFG--------- 250
            ||||||:..|||||.|||.|||||:.:||||||||:|||||||.....|::|..:.
Yeast   198 LSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGQTVATIIMLMMYNDMHFSKCWK 262

  Fly   251 ----MISHII-----------------------------------SQESGKKETFGSLGMIYAML 276
                .|::|:                                   |.|:.:|....|:...:...
Yeast   263 LLKKWITNIMSTLFKALFVKMFMSYNNQQDKMMNNTMLKKDNIKRSSETTRKMLNNSMNKKFNQW 327

  Fly   277 AIGLLGFIVWAHHMFTVGMDVDTRAYF-------TSATMIIAVPTGIKIFSWLATLHGTQLSYSP 334
            ..||                :|...||       .|..:.:|:...:       .|...|..:..
Yeast   328 LAGL----------------IDGDGYFGIVSKKYVSLEITVALEDEM-------ALKEIQNKFGG 369

  Fly   335 AILWALGF-VFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLF 398
            :|....|. ...:.:...||::...::|:..:.:|..:| .|:.|       .|:.|....||:
Yeast   370 SIKLRSGVKAIRYRLTNKTGMIKLINAVNGNIRNTKRLV-QFNKV-------CILLGIDFIYPI- 425

  Fly   399 TGLTLNNKWLKSHFIIMFIG-------VNLTFFPQH-----------------FLGLAGMPRRYS 439
             .||.:|.|        |:|       :|.:|...|                 :..:.|....:.
Yeast   426 -KLTKDNSW--------FVGFFDADGTINYSFKNNHPQLTISVTNKYLQDVQEYKNILGGNIYFD 481

  Fly   440 DYPDAYTTWNIVS 452
            ...:.|..|:|.|
Yeast   482 KSQNGYYKWSIQS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX1	YP_009047267.1	COX1	1..511	CDD:177210	195/533 (37%)
AI4	NP_009307.2	CyoB	1..555	CDD:223913	195/533 (37%)
AI4	NP_009307.2	COX1	13..>240	CDD:278541	143/226 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0843
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002409
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102770
Panther	1	1.100	-	-	O	PTHR10422
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1600
TreeFam	1	0.960	-	-
	8	7.700