DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COX1 and COX1

DIOPT Version :9

Sequence 1:	YP_009047267.1	Gene:	COX1 / 19893533	FlyBaseID:	FBgn0013674	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	YP_003024028.1	Gene:	COX1 / 4512	HGNCID:	7419	Length:	513	Species:	Homo sapiens

Alignment Length:	503	Identity:	385/503 - (76%)
Similarity:	448/503 - (89%)	Gaps:	0/503 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QWLFSTNHKDIGTLYFIFGAWAGMVGTSLSILIRAELGHPGALIGDDQIYNVIVTAHAFIMIFFM 67
            :||||||||||||||.:||||||::||:||:|||||||.||.|:|:|.|||||||||||:|||||
Human     5 RWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFM 69

  Fly    68 VMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALSLLLVSSMVENGAGTGWTVYPPLSA 132
            |||||||||||||||||:||||||||||||||||||||:|.|||.|:|||.||||||||||||:.
Human    70 VMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAG 134

  Fly   133 GIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGISLDRMPLFVWSVVITALLLLLSL 197
            ..:|.||||||.||||||||:||||||:|||||:|||:...::..:.|||||||:|||:||||||
Human   135 NYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSL 199

  Fly   198 PVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGK 262
            ||||..||||||||||||:|||||||||||||||||||||||||||||||||||||||::..|||
Human   200 PVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGK 264

  Fly   263 KETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHG 327
            ||.||.:||::||::||.|||||||||||||||||||||||||||||||:|||:|:|||||||||
Human   265 KEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHG 329

  Fly   328 TQLSYSPAILWALGFVFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFI 392
            :.:.:|.|:||||||:||||||||||:||||||:||:||||||||||||||||||||||||.|||
Human   330 SNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFI 394

  Fly   393 HWYPLFTGLTLNNKWLKSHFIIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNIVSTIGST 457
            ||:|||:|.||:..:.|.||.||||||||||||||||||:||||||||||||||||||:|::||.
Human   395 HWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSF 459

  Fly   458 ISLLGILFFFFIIWESLVSQRQVIYPIQLNSSIEWYQNTPPAEHSYSE 505
            |||..::...|:|||:..|:|:|:...:.:.::||....||..|::.|
Human   460 ISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX1	YP_009047267.1	COX1	1..511	CDD:177210	385/503 (77%)
COX1	YP_003024028.1	COX1	5..507	CDD:177210	384/501 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160351
Domainoid	1	1.000	771	1.000	Domainoid score	I81
eggNOG	1	0.900	-	-		E1_COG0843
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	829	1.000	Inparanoid score	I463
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61018
OrthoDB	1	1.010	-	-		D319716at33208
OrthoFinder	1	1.000	-	-		FOG0002409
OrthoInspector	1	1.000	-	-		oto89658
orthoMCL	1	0.900	-	-		OOG6_102770
Panther	1	1.100	-	-	LDO	PTHR10422
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R244
SonicParanoid	1	1.000	-	-		X1600
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800