DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rp1 and Su(var)2-HP2

DIOPT Version :9

Sequence 1:NP_035413.1 Gene:Rp1 / 19888 MGIID:1341105 Length:2095 Species:Mus musculus
Sequence 2:NP_610972.2 Gene:Su(var)2-HP2 / 36621 FlyBaseID:FBgn0026427 Length:3257 Species:Drosophila melanogaster


Alignment Length:2136 Identity:392/2136 - (18%)
Similarity:717/2136 - (33%) Gaps:564/2136 - (26%)


- Green bases have known domain annotations that are detailed below.


Mouse     2 SDTPSTSFSMIHLTS--EGQVP----SPRHSNITHPVVAKRISFYKSGDPQFGGVRVVVNPRSFK 60
            |.|.|.:.::..:.|  |||.|    :.||:|       .:.||..|               :::
  Fly   269 SRTTSVADTVTPVVSDDEGQEPQSELNQRHAN-------DQESFLSS---------------TYE 311

Mouse    61 TFDALLDSLSRKVPLPFGVRNISTPRGRHSITRLEELEDGKSYVCSHNKKVLPVDLDKARRRPRP 125
            ...:.|.:||...|.|...:..|..:.|.:     |.:...|....|..:.......:|.::.| 
  Fly   312 RLQSYLSNLSSAEPPPIYKKQNSARKSRSN-----EKKPSSSQQVKHANEQSAASDKEANKKER- 370

Mouse   126 WLSSRSISTHVQLCPATANMSTMAPGMLRAPRRLVVFRNGDPKNKHVVLLSRRITQSFEAFLQYL 190
                       .|.|..|:.|..:.....:..|.:.    |..|...:....|::      |...
  Fly   371 -----------DLEPPEASSSAKSSASKASGSRKLY----DVANNATLEAVERMS------LDLA 414

Mouse   191 TQVMQCPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPAKLPGISHRVHQ 255
            .|:|:..|.:.|..:.|.....:::   |.:.:.|.....:.|:.        .||...|.|:.|
  Fly   415 EQIMEIDVERSYEFEKRSASKSRSL---SRSKIPADSSTSQLGHV--------RKLTYSSERLDQ 468

Mouse   256 KGKAKIE-KRKMSTHMPSDLRPQ-------TDSLISEKTYDCFSDFSVAP--------------E 298
            ......: :|..|..:|...||:       ..:.:.||:.:| .|....|              |
  Fly   469 PEPLGTQLRRSKSESLPKRGRPRGQKQRKNRGATMEEKSANC-RDGEGEPVKRKRGRPRKIIPKE 532

Mouse   299 NYLALETHES-QSLSTYPSEDDVEKSIVFNQDGTMTVVMKVRFKIKEEETVKWTTTVNRAGLSNN 362
            .....||..: :||:|     :|..||..:::...|..:.:...||::|.|             :
  Fly   533 EAKTAETENTIESLNT-----NVPLSIDTSKENPETETVNLEVPIKQDELV-------------S 579

Mouse   363 DEKNKKSSYPGKTDYGPSSLKLEACSLPEDIVDTTQQGSLTEEENTQMTEQQALSCSSASWENAS 427
            |..|.| ...|.|:.....:::.:.....|:.....:.:|.:.|:|...|::.|.......:.|.
  Fly   580 DLDNAK-ELTGSTNLPQDDIEMASNHQETDLKCAPDRVALDKSESTPKVEEEQLCKVDTPSDTAL 643

Mouse   428 METDIQESQKQVKHFYRPPTPGPRRMRQKKSVIG--------TVTVVSETEVQEKQ--------- 475
            .|:.:.||.|  .|.........:...||:|..|        :|.|.:|.|:..|:         
  Fly   644 DESKVSESAK--NHIELEDKDKDKEETQKESPNGNSKETNENSVIVTNEVELPAKKAEAKAEAGN 706

Mouse   476 ------------FSYSEE------RKGGEKSEYHMFTHSCSKMSSVSNKLVQIGSDNEMESALE- 521
                        |..:||      .||.|.:|.     |.:.:....|.:::|..:.|.|:..| 
  Fly   707 IVEESDSQLAEDFKLAEEILAAEVGKGVEANEV-----SVTSVQGEQNPVIEIVKELEQETISEV 766

Mouse   522 --RTRESGSLKSQAINAGAIEITSQKVLKMCHNNALPSTAPENSVVEEGTDNSAVSGTATIKHFR 584
              ...:..|::.|.:......:.....:|      .||::.:....||...              
  Fly   767 VPAQNDQSSVEDQTLADKENPVEKPSPVK------APSSSKDEPPAEENLP-------------- 811

Mouse   585 TCGNANDSFSSITADSTPTSVNNYSNDRNISELPSVGS------PVLTMRLVNEFAHCGLTEKPE 643
                |.|. ..|....||.: .|..:|:..:|.|...|      |..::....:..|......|:
  Fly   812 ----APDQ-DPIEQQKTPVA-KNQQHDKEHNEAPKAESLSVSDIPSSSVTPSKKRNHSSPANTPK 870

Mouse   644 NRKKV--LSSSASKK--KKKKSQQRMITSNDKKKVIET-----------KGPPNIAGKIPRAGTT 693
            ..|::  |.||..::  :..|:..:.:..:..|:.::|           :..|.: |:.|....:
  Fly   871 KSKEIEALQSSVPRRALRSDKATPQNLRESRSKRTLKTELTLLMDDTMRRSSPRL-GRSPAESHS 934

Mouse   694 AQERLLQESDCPDKGGRVCEQGLNISPMA-----------IESNNFFPKSNPTFSKNFYK----- 742
            :.||            ...|:.:.:|.:|           ||..: .|.::.|......|     
  Fly   935 SHER------------SPMEKKVTVSKLAKDLITIDKEKEIELKS-LPDASETKDVKITKTTTAS 986

Mouse   743 -NKLNTFQNPKTQKL-LAKRKSRPRKIVSTERLRKQEI------GQEDKILLHSDSKLCESHLEK 799
             ..:.|.:||.:.|. :.|.|.:|.|.....|..:.|:      ..||...:.| .|..|.||..
  Fly   987 DTSILTDENPSSSKTEMKKLKGKPLKAKKMSRTSETEVKKAIADSNEDIPSIFS-IKCVEEHLTS 1050

Mouse   800 QSLFHVFNILEEDQK----VLHRPPFQVEKVARNL-KGMAKKSLVPKVNDLHIMLRNQKKQMGVK 859
            .         |.:||    .|..|..|::....:| :..|.::...:|.:.....|..::....|
  Fly  1051 S---------ESEQKDEKEELLCPKPQIDCTNTDLEQSTAIETDTEQVEEKRSNRRKSRRIRNEK 1106

Mouse   860 LKSGAEVSEQHV---------------------TTRADPL---------------------ASLK 882
            .|:..:....|:                     |.::||:                     |..:
  Fly  1107 FKTETDTLSDHLDAKKAENASLEISMRPKCTLETQQSDPVTAKNKRNSGRLSRKEKSVINAAKSE 1171

Mouse   883 KPDFPEGIPHHSGKSYVKRWLQNINSYPDFEHRKS-----------GPL----CQNRSDVVNYNR 932
            |...|..|...:.:.      |.:|..|..:.:|:           |||    ..:.:::::...
  Fly  1172 KDKSPSAISQSTERK------QLLNENPSKKDKKTEQSGNKKEAVVGPLDKTETSSSTNIIDKKS 1230

Mouse   933 NGFLGNNLHTT---SSKGNGFLMESNKSKTKN---------DNWS--GNTN---QETGKSLVAKD 980
            |....:.:..:   :.|.:.|...|:.|..|.         |..|  |::|   ::||:.....|
  Fly  1231 NESFDSAMQPSDRLNQKESAFTKLSSISSPKKIMKDQDKDLDALSKGGDSNPTIRDTGEDSRQTD 1295

Mouse   981 NGEELN--KHHCESQN---GSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKSRPEVKLVYQE 1040
            ...:.|  ||..|..:   .::.::...|..|...:|:.: ::.|.|..||..|||.:.|...::
  Fly  1296 KKHQENDTKHEEEDSSKLKANIDETKSSSEKDAEPISKDS-SQDSAKPRLSKPKSRNKRKKNEKK 1359

Mouse  1041 MNFATKRQSIEVAIQVD---------TMGENVLKDYL--------PAL-------LLRHLEAFVP 1081
            .|.:.....||...||:         |..|:..||.:        |.|       :.:..:||..
  Fly  1360 PNDSIAESDIEGGFQVNTETVQATCSTPSESNKKDMVKSDETNEEPNLSETEIGRIRKRGQAFHI 1424

Mouse  1082 NNQKH------QNGISQIPGSLAE--VVFPSVIDNSSTNLLLAWLLVLNLKRTMNSFCQSDAHKM 1138
            .|.|.      ||....|.|...|  |..|..:::.:.        ::.:.......|..:...:
  Fly  1425 ENPKDDLHITPQNENQSIAGVNFEKQVPLPESVESDTP--------IMKIPTKTYLMCTKNKTSL 1481

Mouse  1139 TNRPSETAALLEVLKHVAITEEADDLKAAVANLMESTKTCSGSSGREQDMLPVNCTASSLHSVDE 1203
            .:...:...:||..|.:.                    |..|.|..:.|    |.......|..:
  Fly  1482 LSASEDPDIVLEPQKLIT--------------------TSKGDSNPDLD----NANNLETSSTQD 1522

Mouse  1204 CNENGSAQKTLLDEGYSVMGDCTSEMVSKSCNSSCEMHMVSKTNPPKQVDDQSDGLLTSNSCTVS 1268
            ..|:..:.:|..|.. .::..||.           :..:|..|.|.|..|...:..:|.|....|
  Fly  1523 PKEHEFSDQTFTDNS-DIIPSCTK-----------KSQIVFPTTPTKSSDQTKNSFITPNRSPKS 1575

Mouse  1269 QRSTG-ACFLTDGVYSHEACAQKEGVYEGACLSDETHIPIRDCHTIHSVHSKENKCTDDLESTEE 1332
            :|:.. .....|..:.....|..|.  ..:.:..|...|...|..:..:..:..  |..|.:...
  Fly  1576 KRNVSKEAKRLDNSFEESQNAASES--SASKVQKELRTPTASCRKLRVLIKRTP--TSSLPTNSR 1636

Mouse  1333 LKTVDKVP---KGLSILADSMYKNDSNVSTFQ--NVNKLSSQRTLLSKTYL-DSDKDYSPLEEFQ 1391
            .....|.|   |.|:.:.:||.|..|...:..  .||..|......|...| :||:|.    |..
  Fly  1637 KSIFKKTPAKSKRLTKILESMEKTPSREPSVSLGEVNPDSDPVAAESVAVLHESDRDL----ESN 1697

Mouse  1392 NCPRKKIVNKKKSISSDKEES--RTSEEPRSI-TNSMTSSERNAISELESFEELESQDTSIFNMN 1453
            ..|.:::....:..|::..::  :..|:...: .|.:.::.:|.|:: :|.::..|         
  Fly  1698 EIPNEEVFEDTEEASAEDTDNKLKKKEDDHELEVNDICAASKNPITD-DSTKDASS--------- 1752

Mouse  1454 VRAEKKSTKETMQKQSEARMSSELIN----------------VSGRKIIEQERR----------- 1491
                .|||...:.::::..:|:.|||                |...|.:|.|.:           
  Fly  1753 ----NKSTDSDVLQETKDELSNSLINATQGEDTPIKELTEEEVPNNKTVEDESKKQEILKDLEPD 1813

Mouse  1492 NTAILETTARGQVTPPSLAFCYDSNKNTEKEISEGETKMRVKKMVDSMENESYSESSLNFKKHHR 1556
            |.|:.|.||........:........|.:..::|.||        |..::|..::|.:       
  Fly  1814 NAALEEDTASTAKAAEEMDLYIKEKSNVKSVLAEPET--------DVTDDEELAQSPI------- 1863

Mouse  1557 SPGTLDWSDYGSDSE--SGYPCKASSNSHNDDSGQEKEPTRGIVKRAIEK-LYGKAEIIKPPFFH 1618
             |.:.:.:....|.|  :....|.|......||.|..|..:...::.:|| |.||.|.:||    
  Fly  1864 -PNSSETTSVTDDPEPSTSSVVKRSLRKREADSSQPDEAAKRKQRQDVEKSLTGKKEQVKP---- 1923

Mouse  1619 GSIHKSQVCPYNSVEVQCAKKTNFYESECQSLVSSEQVSRSSLIFQE-------FPQVDANGMGD 1676
              ..:.|:.   .||.:.:.|.:..|||.:|.|..:.:   |:|..|       .|..:.|....
  Fly  1924 --ARRRQLA---EVEERPSLKRSKTESEAKSTVQGKYI---SIIGNETIMSSTTAPIRETNREAA 1980

Mouse  1677 SFGDSSIENVTKSSAHDRVFTEKENGKLI--DNGKWLLRENHLWRVSSDNPGMYGNADTTSVDTL 1739
            |...|:.::..:.:.|  |.|.|.   :|  ..||.||.        ||:|.  .......|.||
  Fly  1981 STSPSARKSAVQEAKH--VETTKH---IILGPPGKKLLH--------SDSPA--AEVKKPMVQTL 2030

Mouse  1740 IDKN-SIEVPYSHFGELAPGPTMAELSSSEIEEMTQPLEVKCNYFNFPHGSDSEPFGEDFPDAQN 1803
            :... |::.|                  |.::: ..||:::        .|..:...::..|...
  Fly  2031 LSSTLSLQKP------------------STLDD-GSPLKIR--------KSLKKSIADENIDGDQ 2068

Mouse  1804 KTCPKEKIPNHHTE----EKGNYPSERLCTSVTQAFVSAGNKVHPVCS--DAIKTQ 1853
            .......:.|.:|.    .|.|.....|.:..||...:|.:...|:.:  :.:|||
  Fly  2069 SIFSSSSVLNKNTSVVAPRKVNISVSLLQSKDTQVETAASSSETPILTKKEKLKTQ 2124

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rp1NP_035413.1 DCX 35..110 CDD:176357 13/74 (18%)
DCX 157..232 CDD:176357 12/74 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..379 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..688 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..887 6/65 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1400..1430 3/32 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1572..1595 6/22 (27%)
Su(var)2-HP2NP_610972.2 MDN1 <596..845 CDD:227596 51/281 (18%)
PTZ00449 <739..1091 CDD:185628 72/406 (18%)
PTZ00108 <1132..1374 CDD:240271 45/248 (18%)
PTZ00121 <1720..>2291 CDD:173412 96/489 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1181
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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