DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a8 and CG4630

DIOPT Version :9

Sequence 1:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	167/571 - (29%)
Similarity:	265/571 - (46%)	Gaps:	72/571 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPPPNASL------EP 59
            :.|.:||..:|..|.||..:..|:.||:|..|.::|..:|||.:|.:.|..|....|      ..
  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGAN 77

Mouse    60 WVLPLGPNG-------KPEKCLRFV----HLPNASLP------------NDTQGATEPCLDGWIY 101
            ||....|..       .|..|.|||    ||.::|.|            |.|. .||.| :.::|
  Fly    78 WVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTT-ETERC-NQFVY 140

Mouse   102 NSTRDTIVTEWDLVCGSNKLK-EMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGS 165
            .|:..|||.:|.|.|..|..| ....::..||::||..:.|.|:||:|||.|..:..:.:|.:|.
  Fly   141 GSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTGV 205

Mouse   166 SAAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAY 230
            :.|.|.....::.|..|.....||:.....|:.||.|....|.:||..:.|.|.:|:.:| ||:.
  Fly   206 AQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL-GLSV 269

Mouse   231 AVPQWRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGK---------- 285
            .:|.||.|||::|....|.....|.||||:|||:...:..:|...::|.|..|.:
  Fly   270 FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDISVELMASF 334

Mouse   286 ------KEEGEKLTVEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSL 344
                  .|.|::..||. ..:::||   .|:...:.::.|..||......|.|.|......||.|
  Fly   335 KQQELDAETGQEDDVEG-GLHVKKD---DKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYGL 395

Mouse   345 AMGVEEFGVNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVS----- 404
            ::.......|.|:...:...|:||...:..|.:...|||:.....|:|..:..:|..||:
  Fly   396 SLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQGD 460

Mouse   405 --------------SEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARV 455
                          |....|...|.:.||..::.||:.::.:|:|:.|||:|..|:|:.:.:||.
  Fly   461 WIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFARF 525

Mouse   456 GSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPLPETIED 506
            |:|:||.|.:.......:|.::|||::|:.|..:..|.||.||.||:|:|:
  Fly   526 GAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	162/556 (29%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	162/556 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	106/379 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030