DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Robo1 and robo3

DIOPT Version :9

Sequence 1:XP_017172382.1 Gene:Robo1 / 19876 MGIID:1274781 Length:1687 Species:Mus musculus
Sequence 2:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster


Alignment Length:1291 Identity:391/1291 - (30%)
Similarity:589/1291 - (45%) Gaps:236/1291 - (18%)


- Green bases have known domain annotations that are detailed below.


Mouse    96 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 160
            |...||||||||.|..|.:.|||||||||||.|||||:|||.|..:   |..|.|||:.||:|.|
  Fly    18 QGSHPPRIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPL---KILPGSHRITLPAGGL 79

Mouse   161 FFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 225
            |||::|:.|: ..|.|:|.|.|:|.||.|.|.||:|:||:|||:||..|.:..:|.|:.|::||.
  Fly    80 FFLKVVNSRR-ETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECA 143

Mouse   226 PPRGHPEPTISWKKDGSPLD---DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 287
            .|||.||||::|||.|..||   .|..|| :.||.|.|...|::|.|:|.|:..|.||.|||.:|
  Fly   144 APRGIPEPTVTWKKGGQKLDLEGSKRVRI-VDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLA 207

Mouse   288 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK--DDGELPKSRYEIRDDHTLKI 350
            .|.|..:|..::.|.:..|....|..|.|...|||:|.|.|.:  ..|.:|..|..:.:|.:|::
  Fly   208 TLKVHVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRL 272

Mouse   351 RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 415
            .:||..|.|.|:|.|:|:||...|..||||..   ||.|:.:|..:.|.||...:|:|.|.|||:
  Fly   273 ERVTIADEGEYSCEADNVVGAITAMGTLTVYA---PPKFIQRPASKSVELGADTSFECRAIGNPK 334

Mouse   416 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD----LTITNVQRSDVGYYI-CQTLNVAGSIIT 475
            |.|||..:.:..|:|...||  ..||....|.:    ||:|..||:|....| |..:|...||.:
  Fly   335 PTIFWTIKNNSTLIFPGAPP--LDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITS 397

Mouse   476 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTLILSCVATGSPAPTILWRKDGVLVSTQDSRIKQ 540
            :..|.: |...|||||:|..||||||:.:.....|.|.|.|.|:|||.|.:||:.|. ..|::..
  Fly   398 RVQLSL-DSQEDRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQ-PSSKLNI 460

Mouse   541 LESGVLQIR-YAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--------- 595
            ..||.|.|. ..:..|.|.|||.||:.:|::|||.::.::         .||:||:         
  Fly   461 TTSGDLIISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIE---------LPTNPNIKFYRAPEQT 516

Mouse   596 -IPSAPSKPEVTDVSKNTVTLSWQPNLNSGATP-TSYIIEAFSHASGSSWQTAAENVKTETFAIK 658
             .||||.:|::.:.:.:.:|:.|..:..:||:. ..|.:|.:......:|...|..:....|.::
  Fly   517 KCPSAPGQPKILNATASALTIVWPTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIFTVE 581

Mouse   659 GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTSQGVDHKQVQREL---------GNVVL 714
            .|...|.|:|:|||.|:.|.|.||.||:|:....:.....|.:.....:.|         .|.|:
  Fly   582 SLTQGAAYMFIVRAENSLGFSPPSPISEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVV 646

Mouse   715 HLHNPTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSVVIPDLRK 779
            .|.......|::..:.|.:| ..|||:|:.:..|...:|  |.:.:....:....:|..:|.|.|
  Fly   647 ELLEANASDSTTARLSWDID-SGQYIEGFYLYARELHSS--EYKMVTLLNKGQGLSSCTVPGLAK 708

Mouse   780 GVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPRSVTVSKNDGNGTAILVTWQPP-PEDTQN 843
            ...||....||:....|..|..:..:|||:.|.|||..:...:  .|.|::.:.|.|| |..|:|
  Fly   709 ASTYEFFLVPFYKSIVGKPSNSRRMRTLEDVPEAPPYGMEAIQ--FNRTSVFLKWLPPQPNRTRN 771

Mouse   844 GMVQEYKVWCLG----NETKYHINKTVDGSTFSVVIPSLVPGIRYSVEVAASTGAGPGVKSEPQF 904
            |::..|.|...|    |.|:...|.|:|.:..::::.:|..|:.|.:.|||:|..|.|..|:|..
  Fly   772 GILTSYNVVVKGLDVHNTTRIFKNMTIDAAAPTLLLANLTTGVTYYIAVAAATRVGVGPFSKPAV 836

Mouse   905 IQLDSHGNPV-SPEDQVSLAQQIS-DVVRQPAFIAGIGAACWIILMVF-SIWLYRHRK--KRNGL 964
            :::|:....: :...:..:::.|: |.:.|..||..:|:...||:.:. ::.|::..:  |:..|
  Fly   837 LRIDARTQSLDTGYTRYPISRDIADDFLTQTWFIVLLGSIIAIIVFLLGALVLFKRYQFIKQTSL 901

Mouse   965 TSTYAG-----IRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPATQPWLADT---WPNTGN 1021
            .|.:..     :||.|:...       .||.||.:||........:.....|:..|   |.....
  Fly   902 GSLHGNHAIGTVRKFPTLPL-------NGGGAVGAGGSNSTAAAGQSGHGLWIDPTSGVWRQAAG 959

Mouse  1022 NHNDCSINCC------------TAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVY 1074
            ..|...:..|            ||..|...:.|..|.|               .:.|.:|:   |
  Fly   960 GGNPGGVGSCTTKEQLPGYAQATAQQGQQPTLLPDYER---------------LSPLNMPD---Y 1006

Mouse  1075 GDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPT-----------------PYATTQLI------- 1115
            .:|..|       ||.||.         .|.|.                 .||||.::       
  Fly  1007 AEVACS-------TFKSPT---------HGAPPMGGGGGGQSASLYDSCGAYATTNVVANVKLYQ 1055

Mouse  1116 --------QANLSNNMNNGAGD--SSEKHWKPPG-------------QQKPEV------------ 1145
                    |::.|||.|:...|  |:..:..||.             ||:|.:            
  Fly  1056 NRYATKPNQSSGSNNNNHQGNDYQSTGMYSAPPSAHYGCLEPKQQQQQQQPNLMTTSTASTAILT 1120

Mouse  1146 ---APIQYNIMEQNKLN----KDYRANDTIPPTIPYNQ---------SYDQNTGGSYNSSDRGSS 1194
               |.::...:.:||::    |..|.|       |:||         :..|..|...|::.....
  Fly  1121 NSPAKVKKINITENKMDQLEGKSERTN-------PFNQQQQLLLASNALKQGLGAYANTTLAAQM 1178

Mouse  1195 TS-GSQGHKKGARTPK-------------------------APKQGGMNWADLLPP 1224
            .| |..|..:..|.||                         ||..|.|::....||
  Fly  1179 ASGGGAGTLRRQRQPKTLYKSENNILGKSGLRQNTMNASVGAPSNGQMDFLTGGPP 1234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Robo1XP_017172382.1 Ig1_Robo 100..199 CDD:143317 57/98 (58%)
Ig2_Robo 207..291 CDD:143201 39/86 (45%)
Ig3_Robo 312..380 CDD:143202 26/69 (38%)
Ig4_Robo 401..490 CDD:143203 33/93 (35%)
I-set 491..578 CDD:369462 36/87 (41%)
FN3 597..683 CDD:238020 25/86 (29%)
FN3 720..806 CDD:238020 20/85 (24%)
fn3 814..897 CDD:365830 27/87 (31%)
robo3NP_608592.2 Ig 22..117 CDD:299845 57/98 (58%)
I-set 23..116 CDD:254352 56/96 (58%)
I-set 122..211 CDD:254352 41/89 (46%)
Ig 125..211 CDD:299845 39/86 (45%)
I-set 215..302 CDD:254352 30/86 (35%)
Ig 232..302 CDD:299845 26/69 (38%)
I-set 306..401 CDD:254352 34/96 (35%)
Ig 320..411 CDD:299845 33/93 (35%)
I-set 412..492 CDD:254352 33/80 (41%)
IGc2 429..489 CDD:197706 24/60 (40%)
FN3 519..612 CDD:238020 29/92 (32%)
FN3 644..735 CDD:238020 22/93 (24%)
fn3 743..832 CDD:278470 28/90 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 104 1.000 Domainoid score I6680
eggNOG 1 0.900 - - E1_KOG4222
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2206
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 1 1.000 - - mtm8796
orthoMCL 1 0.900 - - OOG6_101537
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.670

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