DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a16 and CYP721A1

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_177649.1	Gene:	CYP721A1 / 843850	AraportID:	AT1G75130	Length:	505	Species:	Arabidopsis thaliana

Alignment Length:	541	Identity:	126/541 - (23%)
Similarity:	225/541 - (41%)	Gaps:	95/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSFLLGYLRYRFTY---WELRGIP-QLRPHF----LFGHFFRLQSVHYSELLQETYDA------ 61
            :|..:..:|.:||.|   |    :| :::.||    :.|..:|:.|.:..|:.:.|.:|
plant     6 ILVLVFFFLVFRFIYSNIW----VPWRIQSHFKKQSVTGPSYRIFSGNSGEVSRLTAEAKSKPIP 66

  Fly    62 ---------------FRGSAKVAG-TYVF---LRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGD 107
                           :...::|.| |:::   .:|:....|..|::..|..  ....||  ...:
plant    67 SGRNPHEFVHRVAPHYHEWSRVYGKTFLYWFGSKPVVATSDPRLIREALTT--GGSFDR--IGHN 127

  Fly   108 PLTANLF-----NLQGEEWRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDEL-VGSQGAVL 166
            ||:..|:     .|:|::|...|......||..|:|.....:.|....|...:::: .|.:...|
plant   128 PLSKLLYAQGLPGLRGDQWAFHRRIAKQAFTMEKLKRWVPQMVTSTMMLMEKWEDMRNGGEEIEL 192

  Fly   167 ELHDLMARYTTDVIGSCAFGTECSSLREPQAEFRQVGRRIFRNSNRS------IRWRIFKMTYLS 225
            |:|..|...:.:::...|||   :|:.|        |:.||....|.      :||.::...:..
plant   193 EVHKEMHNLSAEMLSRTAFG---NSVEE--------GKGIFELQERMMRLFYLVRWSVYIPGFRF 246

  Fly   226 SLAKLGLPVRILHPDITKFFNRIVRETVELRERENIRRNDFMDLLLDLRRQENGKGLTMEQMAAQ 290
            ..:|....:..:...|.....:::.......|:.......||....:...||...|:  |::..:
plant   247 FPSKTNREIWRIEKQIRVSILKLIENNKTAVEKSGTLLQAFMSPYTNQNGQEEKLGI--EEVTDE 309

  Fly   291 AFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITET 355
            ...|:.|..||:::.|::.|..||.||:.|...|.|:...:|:.|..|.:.:.::..|...|.||
plant   310 CKTFYFAAKETTANLMTFVLVLLAMNQEWQNIAREEVICVLGQTGLPTLDILQDLKTLSMIINET 374

  Fly   356 LRKYPALSSLTRLASE-----DYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVY-PEPHEFRP 414
            ||.||...:|.|...:     |.:||:           ||.:::.|:|:|:|.|.: .:..||.|
plant   375 LRLYPPAMTLNRDTLKRAKLGDLDIPA-----------GTQLYLSVVAMHHDKETWGDDAEEFNP 428

  Fly   415 ERFAPDACRERHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPG---SPTQLKVT 476
            .||...   ::.....:.||.|||.|:|......:.|..|.|:|:.:.|.|.|.   :|. |.||
plant   429 RRFEDP---KKQSALLVPFGLGPRTCVGQNLAVNEAKTVLATILKYYSFRLSPSYAHAPV-LFVT 489

  Fly   477 KRNLILLPSDGVRLQVDPVES 497
                 |.|.:|..|....:.|
plant   490 -----LQPQNGAHLLFTRISS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	119/510 (23%)
CYP721A1	NP_177649.1	p450	26..495	CDD:386267	117/505 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900