DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a16 and CYP711A1

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_565617.2	Gene:	CYP711A1 / 817157	AraportID:	AT2G26170	Length:	522	Species:	Arabidopsis thaliana

Alignment Length:	537	Identity:	144/537 - (26%)
Similarity:	240/537 - (44%)	Gaps:	93/537 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTSLLSF----LLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETY--DAFRGSA 66
            |.:.|:|    ::.|| || ..|.:..:|......|.||.          .|...|  |.|...|
plant    21 LIAFLTFAAVVIVIYL-YR-PSWSVCNVPGPTAMPLVGHL----------PLMAKYGPDVFSVLA 73

  Fly    67 KVAGTYVF-----LRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGDPLTAN------LFNLQGEE 120
            |..|. :|     .:|:.::.:.:|.:.|.|:.|.:..:|..  ..|::|:      ||..:.:.
plant    74 KQYGP-IFRFQMGRQPLIIIAEAELCREVGIKKFKDLPNRSI--PSPISASPLHKKGLFFTRDKR 135

  Fly   121 WRNLRTKL----SPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIG 181
            |..:|..:    .|:..:..:..|...:::....|.....::|.|        :|..:.|||:||
plant   136 WSKMRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKPRDIVFS--------NLFLKLTTDIIG 192

  Fly   182 SCAFGTECS-SLREPQAEFRQ---VGRRIFRNSNRSIRWRIFKMTYLSSLA-KLGLPVRILHPDI 241
            ..|||.:.. |.::|..:...   :.:.::..:.       .||....||: .|||.:.||....
plant   193 QAAFGVDFGLSGKKPIKDVEVTDFINQHVYSTTQ-------LKMDLSGSLSIILGLLIPILQEPF 250

  Fly   242 TKFFNRI------------------VRETVELRERE-NIRRNDFMDLLLDLRRQEN-GKGL-TME 285
            .:...||                  :.|.|..|.:| .....||:.|:|..|..:. .|.: |.:
plant   251 RQVLKRIPGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARESDPFAKNIFTSD 315

  Fly   286 QMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKL--TYEAMMEMPYL 348
            .::|..:...:||..|::..:|..|:.::.:.||:::|..|| |..|....:  .::...:.|||
plant   316 YISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEI-DGFGNRDLIPTAHDLQHKFPYL 379

  Fly   349 DQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFR 413
            ||.|.|.:|.|.....:.|..:::.||    ||  .:|.|||.|.:.:..:..||:.:|||.:|:
plant   380 DQVIKEAMRFYMVSPLVARETAKEVEI----GG--YLLPKGTWVWLALGVLAKDPKNFPEPEKFK 438

  Fly   414 PERFAPDACRE--RHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRR--FRFSLPPGSPTQLK 474
            ||||.|:...|  |||.||:.||.|||.|:|.||...::|:.|:.|.|.  ||.||....|.||.
plant   439 PERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLD 503

  Fly   475 VTKRNLILLPSDGVRLQ 491
            .   .:||...:||:|:
plant   504 Y---GIILSFKNGVKLR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	136/509 (27%)
CYP711A1	NP_565617.2	cytochrome_P450	75..515	CDD:425388	124/467 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860