DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and tbxas1

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	547	Identity:	158/547 - (28%)
Similarity:	268/547 - (48%)	Gaps:	73/547 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFTLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGH-------FFRLQSVHYSELLQET 58
            :..|:.|....||.|..|....|:..|..||...:|....|:       ||:.|:
Zfish    18 LSLTVCLFLLSLSLLYWYSISPFSNLERCGIKHPKPLPFIGNLMMFRNGFFKSQA---------- 72

  Fly    59 YDAFRGSAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG--DPLTANLFNLQGEEW 121
             |......::.|.|:..|...::.|.|:::.|::::||.|.:|.:..|  .|::.:|..|:||:|
Zfish    73 -DLINKYGRICGYYIGRRSTVIIADPDMLRQVMVKEFNKFPNRMTARGITKPMSDSLIMLKGEQW 136

  Fly   122 RNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFG 186
            :.:|:.|:|||::.|||.|...::|..:.|.........|:.: ..:|.....:|.|||.|.|||
Zfish   137 KRVRSILTPTFSAAKMKEMVPLINTATETLLRNLKSHAESENS-FNIHKCFGCFTMDVIASVAFG 200

  Fly   187 TECSSLREPQAEFRQVGRRIFRNS-NRSIRWRIFKMTYLSSLAKL-GLPVRILHPDITKFFNRIV 249
            |:..|...|...|.....:.|..| .|.|  .||.|.:...|..| ||.......::..||.:.:
Zfish   201 TQVDSQNNPDDPFVHQASKFFAFSFFRPI--MIFFMAFPFLLRLLAGLLPNKSRDEMNSFFTQCI 263

  Fly   250 RETVELRERENI----RRNDFMDLLLDLR-----------------------------------R 275
            ::.:  ::|:::    ||.||:.|:||:|                                   |
Zfish   264 QKMI--KQRDDLSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPANESTKR 326

  Fly   276 QENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYE 340
            .:..:.:|.:::..|:|:|.|||:||||:.:::..:.||.:.:.|:||:.|:::...:|..:.|.
Zfish   327 SQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHETVDYA 391

  Fly   341 AMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEV 405
            .:.|:.|||..|.|:||.||....:.|...||..:      :...|.||.|:.||...:|||||.
Zfish   392 NVQELKYLDMVICESLRLYPPAFRVARDVEEDTVL------NGQFLPKGASLEIPTGFLHYDPEH 450

  Fly   406 YPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSP 470
            :.||.:|.||||.|:|...|||..:|.||.|||:|:|:|..::::||.|:.:.|||.......:.
Zfish   451 WTEPTKFIPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACEDTE 515

  Fly   471 TQLKVTKRNLILLPSDGVRLQVDPVES 497
            ..|:: |.:..|.|.:||.:::...|:
Zfish   516 IPLEL-KSHTTLGPKNGVMVKITEREN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	147/509 (29%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	147/507 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.870