DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	528	Identity:	160/528 - (30%)
Similarity:	258/528 - (48%)	Gaps:	78/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFTLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRP-HFLFGHFFRLQSV-HYSELLQETYDAFR 63
            |:..:|:.|||: .|..|..:....::..|||...| .||....|.|:.: ::.....|.|
Human     9 METWVLVATSLV-LLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKY---- 68

  Fly    64 GSAKVAGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDP---LTANLFNLQGEEWRNL 124
              .::.|.|...:||.|::|.|::|.||::: ::.|.::...  .|   |.:.|...:.|||:.:
Human    69 --GEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPL--GPMGFLKSALSFAEDEEWKRI 129

  Fly   125 RTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGS------QGAVLELHDLMARYTTDVIGSC 183
            ||.|||.|||.|.|.|...:|    |.|   |.||.|      ....:.|.|....||.|||...
Human   130 RTLLSPAFTSVKFKEMVPIIS----QCG---DMLVRSLRQEAENSKSINLKDFFGAYTMDVITGT 187

  Fly   184 AFGTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKL------------GLPVRI 236
            .||....||..||..|       .:|..     ::.|:.:|.....|            .|.:.:
Human   188 LFGVNLDSLNNPQDPF-------LKNMK-----KLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

  Fly   237 LHPDITKFFNRIVRETVELRERENIR-RNDFMDLLLD---LRRQENGKGLTMEQMAAQAFVFFVA 297
            ...|:|.|....:....|.|.::..: |.||...::|   .:..::.|.|:..::.||:.:...|
Human   241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFA 305

  Fly   298 GFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPAL 362
            .::|:|:.:.:.::|||.:.||||||:.||:..:.....:||:|:::|.|||..:.||||.:|.:
Human   306 AYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVV 370

  Fly   363 SSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPE-RFAP------D 420
            |.:||:..:|.||      :.|.:.||.:|.:|:.|:|:||:.:.||.:|.|| ||:.      |
Human   371 SRVTRVCKKDIEI------NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSID 429

  Fly   421 ACRERHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNL-ILLP 484
            ..|      ::.||.|||||||:||....:|:.:|..|:.|.|.  |...||:.:...|| ||.|
Human   430 LYR------YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK--PCKETQIPLKLDNLPILQP 486

  Fly   485 SDGVRLQV 492
            ...:.|:|
Human   487 EKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	150/495 (30%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	150/495 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820