DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	517	Identity:	152/517 - (29%)
Similarity:	267/517 - (51%)	Gaps:	52/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FTLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSE-LLQETYDAFRGSA 66
            :||::|...|.|:.|...:|| :.:| |||..||....|..     :.|:: |.....:..:...
Zfish    11 WTLVVLVITLLFIYGVWPHRF-FIKL-GIPGPRPWPFVGTL-----LSYAKGLCNFDMECAKKYG 68

  Fly    67 KVAGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRR---SFHGDPLTANLFNLQGEEWRNLRTK 127
            ||.|.|....|:.:|.||:::|.||::: ::||::||   :....|.:..:..::.|.|:.:|:.
Zfish    69 KVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWKRMRST 133

  Fly   128 LSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTECSSL 192
            |||.||||::|.:|....|.|.:......:....|  .:::.:::|.|:.|||.|.:|..:..|:
Zfish   134 LSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQ--PVKIKEVVAPYSLDVITSSSFSVDIDSI 196

  Fly   193 REPQAEFRQVGRRIFRNSNRSIRWRIFKMTYL-----SSLA----KLGLPVRILHPDITKFFNRI 248
            ..|:..|       ..|..:.|::.:|....|     .|||    |:|  |.:.......||..:
Zfish   197 NNPEDPF-------VINVKKFIQFNMFNPLLLLILLFPSLAIPLKKMG--VTLFSKSAMDFFYSV 252

  Fly   249 VRETVELRERENIRRNDFMDLLLDLR-----------RQENGKGLTMEQMAAQAFVFFVAGFETS 302
            :::..:...:|:..|.||:.|:|..:           .::..||||..::.:|:.||.:.|:||:
Zfish   253 LKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGGYETT 317

  Fly   303 SSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTR 367
            |:.:::.|:.||.|.|..:||..||:.:......:||:|:|.|.||:..|.|::|..|....|.|
Zfish   318 STTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMRMDYLEMAINESMRLLPTAPRLER 382

  Fly   368 LASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLG 432
            .|.:...|      :.:.:.:||.|.||...:.:||:::..|.|||||||:|:...|....||:.
Zfish   383 SAKKTVVI------NGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFIP 441

  Fly   433 FGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDP 494
            ||.|||||||:|:..|.:|:.::.||:  .||:.....||:.: :.|:...|...:.|::.|
Zfish   442 FGLGPRNCIGMRYAVMIMKLFVVKLLQ--NFSVETCKETQIPL-EMNVTFQPKVPITLKLIP 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	140/484 (29%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	137/471 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820