DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	525	Identity:	147/525 - (28%)
Similarity:	265/525 - (50%)	Gaps:	64/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQ-SVHYSELLQETYDAFRGSAK 67
            |..||..|.:.|:.|..:...|::..|||..:....||...|.: ..|..::     |.|....:
Zfish     7 TWTLLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFGTMLRYKDGFHVFDM-----DCFEKYGR 66

  Fly    68 VAGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDPLTANLFN----LQGEEWRNLRTK 127
            :.|.|...:|:..::|..::|.|||:: ::.|.:||:|.   |...|::    .:.::||.:|:.
Zfish    67 IWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFR---LNGALYDAVSIAEDDDWRRIRSV 128

  Fly   128 LSPTFTSGKMKYMFGTVS----TVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTE 188
            |||:||||::|.|||.:.    .:...:|.|     ..:|...::.:....|:.||:.|.||..:
Zfish   129 LSPSFTSGRLKEMFGIMKKHSHILVDSMGKT-----AKRGESADIKEFFGAYSMDVVTSTAFSVD 188

  Fly   189 CSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYL---------SSLAKLGLPVRILHP-DITK 243
            ..||..|:..|       ..|..:.:::.:....:|         ..|.|:..   .|.| .:|.
Zfish   189 IDSLNNPKDPF-------VTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDF---ALFPTSVTD 243

  Fly   244 FFNRIV------RETVELRERENIRRNDFMDLLLD----LRRQENG----KGLTMEQMAAQAFVF 294
            ||...:      |:|..:.:....:|.||:.|::|    ::.:.:|    |||:..::.:|:.:|
Zfish   244 FFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMIF 308

  Fly   295 FVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKY 359
            ..||:|||||.:|:..:.||.|.:..:||:.||:::......:.||.:|.|.|||..::|:||.:
Zfish   309 IFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAPVDYETLMSMDYLDAALSESLRLF 373

  Fly   360 PALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRE 424
            |..:.|.|:..:..||      :.:::.|...|.:|..|:|.||:.:.||..|:||||.......
Zfish   374 PVAARLERVCKKTVEI------NGLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKES 432

  Fly   425 RHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVR 489
            ..|..::.||.|||||||:||.::.:|:.::.:|:||..|:...:...|:: ..|.:|.|.|.::
Zfish   433 IDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLEL-GFNGLLSPKDPIK 496

  Fly   490 LQVDP 494
            |::.|
Zfish   497 LKLQP 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	137/493 (28%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	137/493 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820