Protein Alignment Cyp6a16 and cyp3a4.2

DIOPT Version :10

• Sequence 1: NP_001285631.1
• Gene: Cyp6a16 / 19836250
• FlyBaseID: FBgn0031726
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001015786.1
• Gene: cyp3a4.2 / 548503
• XenbaseID: XB-GENE-971750
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 518
• Identity: 170/518 - (32%)
• Similarity: 255/518 - (49%)
• Gaps: 72/518 - (13%)

  Fly     4 TLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKV 68
            |.:||.:||..:|.|..:.:.|::..|||...|....|.|...:    ..::|...:.|:...|:
 Frog    11 TWILLAALLVLILLYGIWPYGYFKKMGIPGPTPLPFIGTFLEFR----KGMVQFDTECFKKYGKM 71

  Fly    69 AGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFH-GDPLTANLFNLQGEEWRNLRTKLSPT 131
            .|||...:|:..::|..::|.:|::: :.||.:||:|. ..|..:.:...:.|:|:.:|..||||
 Frog    72 WGTYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLNGPFESAITIAEDEQWKRIRNVLSPT 136

  Fly   132 FTSGKMKYMFGTVSTVAQQLGGTFDELVGS-QGAV-----LELHDLMARYTTDVIGSCAFGTECS 190
            |||||:|.||       |.:....|.||.: ||.|     ....|::..|:.|||.|.:|.....
 Frog   137 FTSGKLKEMF-------QIMKDYSDILVKNIQGYVEKDEPCATKDVIGAYSMDVITSTSFSVNID 194

  Fly   191 SLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKL------------GLPVRILHPDITK 243
            ||.:|...|      :....      ::.|...||.|..|            ||.:..:..|.|:
 Frog   195 SLNKPSDPF------VIHMK------KLLKTGLLSPLLILVVIFPFLRPILEGLNLNFVPKDFTE 247

  Fly   244 FFNRIVRETVELRER-ENIRRNDFMDLLLDLRR------QENGKGLTMEQMAAQAFVFFVAGFET 301
            ||...|....|.|:: ::..|.|.:.|::|.|.      ....|.||..::.||:.:|.|||:||
 Frog   248 FFMNAVTSFREKRKKGDHSGRVDLLQLMMDSRTTGGNDLSNKHKALTDAEIMAQSVIFIVAGYET 312

  Fly   302 SSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLT 366
            :|:.:||..:.||.:.||||:|..||:..:......||:.:|:|.|||..|.||||.:|....|.
 Frog   313 TSTALSYLFYNLATHPDVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLE 377

  Fly   367 RLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFL 431
            |::.::.||      :.|.:.||....||...:..|||.:|||.|||||||:.:......|..||
 Frog   378 RVSKQNVEI------NGVSIPKGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKENRATHTPFTFL 436

  Fly   432 GFGDGPRNCIGLRFGRMQVKVGLITLLRRF------------RFS----LPPGSPTQLKVTKR 478
            .|||||||||||||..:.:||.::|||:.|            .||    |.|..|..||...|
 Frog   437 PFGDGPRNCIGLRFALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIGFLQPKKPIVLKFLSR 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	CYP6-like	64..489	CDD:410679	154/458 (34%)
cyp3a4.2	NP_001015786.1	CYP3A	67..495	CDD:410743	151/452 (33%)