DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	226/501 - (45%)
Similarity:	317/501 - (63%)	Gaps:	19/501 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSV-HYSELLQETYDAFRGS-AK 67
            |.|:..:||.|:...|.|..||:.||||....|.|||:.....:. |.:|:.::.|..::.| ..
  Fly     4 LALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIFRDYYFKYKNSDYP 68

  Fly    68 VAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG---DPLTANLFNLQGEEWRNLRTKLS 129
            .||.:.|....|||.|::|:|.|||:|||:|.:|..|:.   |||:|.||:::|::||:||.||:
  Fly    69 FAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQKWRHLRHKLT 133

  Fly   130 PTFTSGKMKYMFGTVSTVAQQLGGTF-DELVGSQGAVLELHDLMARYTTDVIGSCAFGTECSSLR 193
            |||||||||.||..|..|.:::...| .:....:|.|||:.||:||||.||||:||||..|:||.
  Fly   134 PTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNCNSLY 198

  Fly   194 EPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVELRER 258
            :|:|||..:|:|............||...:.....:|.|.:.|  .:...|:.:|||||::.|.|
  Fly   199 DPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSRRLRLKLNI--QEAEDFYTKIVRETIDYRLR 261

  Fly   259 ENIRRNDFMDLLLDLRRQENG----KGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELAKNQDV 319
            ...:||||||.|:::.:.|..    .|||..::.||||:||||||||||:.|.:||:|||:||||
  Fly   262 TKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDV 326

  Fly   320 QQKLRMEINDSIGKHGK-LTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDP 383
            |.|||.||.:..|||.| .|||.:.||.||:|.:.|||||||.|:.|||:...|:   ||:  ||
  Fly   327 QDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDF---SPE--DP 386

  Fly   384 -VVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGR 447
             ..:.|||.|.||.|.|||||::||||..|:||||..:....|....:|.||:|||||||||||.
  Fly   387 KYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGM 451

  Fly   448 MQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVD 493
            ||..|||..|:|.::||:.|.:...:|:..:|:::...:|:.|:|:
  Fly   452 MQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	213/471 (45%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	208/448 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970