DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a16 and Cyp317a1

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	161/525 - (30%)
Similarity:	273/525 - (52%)	Gaps:	63/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFR----------LQSVHYSELLQETYD 60
            ||:..||..|:...||:..||....||..||..|:....:          :::.|||.:    |.
  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAI----YK 70

  Fly    61 AFRGSAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSF---HGDPLTANLFNLQGEEWR 122
            .|:||....|.|..|:|.|::||.:|::.::|:||.||.||..:   ..|||:.:|:.|:||.|:
  Fly    71 KFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDLYALRGESWK 135

  Fly   123 NLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQ-GAVLELHDLMARYTTDVIGSCAFG 186
            .:|.||.|:....:|..::..:...|:||..|.:..:.|| .:.:.:..:|.||....:..|.||
  Fly   136 EMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSSLAKCVFG 200

  Fly   187 TECSSLRE-PQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLP--VRILHPDIT-----K 243
            ......:. |..:|.|: ..:..||:        |..||.:|..:..|  .|:|....|     :
  Fly   201 LNAEQRKTYPLEDFEQM-TELALNSH--------KHGYLMNLMMIRFPNFCRMLRMRRTPKQAEE 256

  Fly   244 FFNRIVRETVELRERENIRRNDFMDLLLDLR-------RQENGKGL---TMEQMAAQAFVFFVAG 298
            :|.:::...||.||.....:.|::.||:|::       :.|..|.|   ...::||.|.||..||
  Fly   257 YFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAG 321

  Fly   299 FETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKH-GKLTYEAMMEMPYLDQTITETLRKYPAL 362
            :|.:::.:||.|:|||.:.::|.::|.|:..:|.:| |.:|:|.:..:.::.|.|.||||.:|..
  Fly   322 YEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPIT 386

  Fly   363 SSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFA--PDACRER 425
            ..:.|....||.:|.   ....:|.|...:.||..|||:||::||:|.||:|:|::  .|:.:|:
  Fly   387 PYILRRTLNDYAVPD---HPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQ 448

  Fly   426 HPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRL 490
              ..:.|||.|.|:|||::|.::|:::.|..||..:.|||.         |::.||.| .||:.|
  Fly   449 --GTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLN---------TRKPLINL-EDGIAL 501

  Fly   491 QVDPV 495
            .:.|:
  Fly   502 TLMPL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	150/494 (30%)
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	134/444 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070