DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a16 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	240/515 - (46%)
Similarity:	336/515 - (65%)	Gaps:	29/515 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFTLLLL---TSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQ---SVHYSELLQETY 59
            |..|.:|.   .:||:.|..|:..:.||::.||||.:.||.:.|:...||   ::|  |:.|:.|
  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIH--EIFQDHY 63

  Fly    60 DAFRGS-AKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG---DPLTANLFNLQGEE 120
            :.||.| |...|.:.|..|.|.|:||:|.|.:||:||:||.::..|:.   ||::|:||||.|.:
  Fly    64 NKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQ 128

  Fly   121 WRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAF 185
            ||.||.|||.||||||||.|:.||.:||.:......|.| .:.:|||:.||:||:|.||||:|||
  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKV-PKNSVLEIRDLVARFTVDVIGTCAF 192

  Fly   186 GTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVR 250
            |.:|:|||:.:|||...|:|...:.........|..:|.....|||: ||.. |.|.:|::|||.
  Fly   193 GIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGM-VRTA-PHIQEFYSRIVT 255

  Fly   251 ETVELRERENIRRNDFMDLLLDLRRQ-----ENG---KGLTMEQMAAQAFVFFVAGFETSSSNMS 307
            |||.:||:|:|:||||||:|::|:.|     |||   :|||||::.|||||||:||||||||.|.
  Fly   256 ETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMG 320

  Fly   308 YALFELAKNQDVQQKLRMEINDSIGKHGK-LTYEAMMEMPYLDQTITETLRKYPALSSLTRLASE 371
            :||:|||||.|:|.|:|.|:.:.|.:|.: .|||...::.||:|.:.||||.|..:.:|.|:|::
  Fly   321 FALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAK 385

  Fly   372 DYEIPSPDGGDP-VVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGD 435
            .|.:|    |.| .|:|.|.||.||..|||:||.:||||.|||||||:|:....|...|:|.|||
  Fly   386 RYVVP----GHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGD 446

  Fly   436 GPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDPV 495
            |||||||||||:||.::||..|:|.|:||....:|..|....::.:|...||:.|:|:.|
  Fly   447 GPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVETV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	226/476 (47%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	225/472 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970