DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	227/507 - (44%)
Similarity:	323/507 - (63%)	Gaps:	23/507 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFTLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRL-QSVHYSELLQETYDAFRG 64
            |...|.|:..|:|.||...|.|..||:.||||...||.::|:.... :..|.:.:.::.|..::.
  Fly     1 MSLLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKR 65

  Fly    65 SA-KVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG---DPLTANLFNLQGEEWRNLR 125
            |. ..||.|.|....||:.||:|||.|||:|||:|.:|..|:.   |||:|.||:::|::||:||
  Fly    66 SVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWRHLR 130

  Fly   126 TKLSPTFTSGKMKYMFGTVSTVAQQLGGTFD-ELVGSQGAVLELHDLMARYTTDVIGSCAFGTEC 189
            .||:|||||||||.||..:..|.:::...|. :....:|.|||:.||:||||.||||:||||..|
  Fly   131 HKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNC 195

  Fly   190 SSLREPQAEFRQVGRR--IFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRET 252
            :||:.|.|||..:|:|  |.|.....:.:.||....||...:|.|.|:    |:..|:..|||.|
  Fly   196 NSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQ----DVEDFYTSIVRNT 256

  Fly   253 VELRERENIRRNDFMDLLLDLRRQENG----KGLTMEQMAAQAFVFFVAGFETSSSNMSYALFEL 313
            ::.|.|.|.:|:||||.|:::..:|..    .||:..::.||||:||||||||||:.|.:||:||
  Fly   257 IDYRLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYEL 321

  Fly   314 AKNQDVQQKLRMEINDSIGKH-GKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPS 377
            |.:||:|.:||.|||:.:.|| .:.|||.:.||.||:|.:.|||||||.|:.|||:...|:   |
  Fly   322 ALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDF---S 383

  Fly   378 PDGGDP-VVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCI 441
            |:  || ..:.|||:|.||.|.||||||:||||.:|:||||..:|...|....:|.||:||||||
  Fly   384 PE--DPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCI 446

  Fly   442 GLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVD 493
            |||||.||..|||..|:|.::||:...:...:|...::::|...:|:.|:|:
  Fly   447 GLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	212/473 (45%)
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	210/467 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970