DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	219/500 - (43%)
Similarity:	327/500 - (65%)	Gaps:	18/500 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TLLLLTSLLSFLLGY--LRYRFTYWELRGIPQLRPHFLFGHFFRL-QSVHYSELLQETYDAFRGS 65
            |||:|...:..|| |  ||:.::||..||:...||.:..|:...| :.:|::::....|..|||.
  Fly     3 TLLVLVFTVGLLL-YVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGV 66

  Fly    66 AKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG---DPLTANLFNLQGEEWRNLRTK 127
            .:..|.:.|:.....::||:|::.::||||::|.||..||.   ||||.||..|.|.|||.||..
  Fly    67 ERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQN 131

  Fly   128 LSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTECSSL 192
            |:..|||||||:||..:..|.::|.......||.    :|..||.||:|||||||||||.||:||
  Fly   132 LTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGE----IEAKDLCARFTTDVIGSCAFGLECNSL 192

  Fly   193 REPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVELRE 257
            ::|:::||::||.:.:....|:..:.|.........||..  |:..|::::||...||:|::.|.
  Fly   193 QDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRF--RLFRPEVSEFFLDTVRQTLDYRR 255

  Fly   258 RENIRRNDFMDLLLDLRRQENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQK 322
            ||||.|||.:.||::|..:.....|:.||:||||.|||:|||:|||:.||:.|:|||.|.|||::
  Fly   256 RENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALNPDVQER 320

  Fly   323 LRMEINDSIGKHG-KLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVL 386
            ||:|:...:.::. ||||:::.|||||||.:.|||||||.|..|.|.::::|:||:.:    ::|
  Fly   321 LRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIPNSN----LIL 381

  Fly   387 EKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGRMQVK 451
            |.|:.:.|||.:||:|||:||:|.:|.|.||.|:..:.|||.|:|.||:|||||||.|||::|||
  Fly   382 EPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVK 446

  Fly   452 VGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDPVE 496
            |||:.|||.|:||....:...||.:.||.::...:||.|:::.:|
  Fly   447 VGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGLE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	205/464 (44%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	202/452 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970