DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	153/503 - (30%)
Similarity:	264/503 - (52%)	Gaps:	39/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLTSLLSFLLGYLRYR-----FTYWELRGIPQLRPHFLFGHF--FRLQSVHYSELLQETYDAFR 63
            |:...|...::|||.|:     |..:|.|.:...:|:...|:.  ..||...:...|.|.|:..|
  Fly     3 LIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYERTR 67

  Fly    64 GSAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGDPLTAN--LFN-----LQGEEW 121
             ..|:.|.:....||..:.|.:|:|.|.::||::|.:.:.|    :|:|  |||     ::.:.|
  Fly    68 -QHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPF----ITSNDRLFNDMLSVMRDQRW 127

  Fly   122 RNLRTKLSPTFTSGKMKYMF----GTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGS 182
            :::|..|:|.||:.||:.||    .:.:...|.|..:...|.|.:|..:::..:..:.:.|:|.:
  Fly   128 KHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIAT 192

  Fly   183 CAFGTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITK--FF 245
            .|||.:.:|...|:.||.::|:.:.  .:|.:::  ||....:.:.||...:::...|..|  :|
  Fly   193 TAFGLKVNSYDNPKNEFYEIGQSLV--FSRGLQF--FKFMLSTLVPKLFSLLKLTIFDSAKVDYF 253

  Fly   246 NRIVRETVELRERENIRRNDFMDLLLDLRRQENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYAL 310
            .|:|.|.::.||:.||.|.|.:.||::.:.:...| .|.:::.||.|:||.|.||.:|:.:....
  Fly   254 ARLVVEAMQYREKHNITRPDMIQLLMEAKNESEDK-WTDDEIVAQCFIFFFAAFENNSNLICTTT 317

  Fly   311 FELAKNQDVQQKLRMEINDS--IGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDY 373
            :||..|.|||::|..||.::  ......|||:|:.:|.|:|..|:|:|||:...::..||.|:||
  Fly   318 YELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDY 382

  Fly   374 EIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPR 438
            .:...||......:.|..::||:..:|.|...:|||.:|.|:||:.:...:..|..:|.||.|||
  Fly   383 TLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPR 447

  Fly   439 NCIGLRFGRMQVKVGLITLLRRFRFSLPP-------GSPTQLKVTKRN 479
            ||||.|:..||||..|..||..::....|       ||.:....|.|:
  Fly   448 NCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	144/472 (31%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	140/450 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970