DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	145/510 - (28%)
Similarity:	245/510 - (48%)	Gaps:	69/510 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGH----FFRLQSVHYSELLQETYDAFRGS 65
            |.::.::|:.:..:|.:.|:||:.||||..:.....|.    |.:.::|.|.  :.|.|:.::.:
  Fly     8 LFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYD--IDEIYEQYKNT 70

  Fly    66 AKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG-----------DPLTA-NLFNLQG 118
            ..:.|.:....|..:|...:....:.:.||      ||||.           ||:.| |.|.|.|
  Fly    71 DSIVGVFQTRIPQLMVTTPEYAHKIYVSDF------RSFHDNEMAKFTDSKTDPILANNPFVLTG 129

  Fly   119 EEWRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAV-----LELHDLMARYTTD 178
            |.|:..|.:::|..::.::|..:.....|.::    |.|.:..|..:     |...||...|||:
  Fly   130 EAWKERRAEVTPGLSANRVKAAYPVSLRVCKK----FVEYIRRQSLMAPAQGLNAKDLCLCYTTE 190

  Fly   179 VIGSCAFGTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLP------VRIL 237
            ||..|..|....|..:.......:.:|:|..|        |...:.:.:|.|..|      |.:.
  Fly   191 VISDCVLGISAQSFTDNPTPMVGMTKRVFEQS--------FGFIFYTVVANLWPPITKFYSVSLF 247

  Fly   238 HPDITKFFNRIVRETVELREREN---IRRNDFMDLLLDLRRQENGKGLTMEQMAAQAFVFFVAGF 299
            ..|:..||..::::.:::| ||:   .:|:||::.:|.|:.:   |||...::.:....|...||
  Fly   248 AKDVAAFFYDLMQKCIQVR-RESPAAQQRDDFLNYMLQLQEK---KGLNAAELTSHTMTFLTDGF 308

  Fly   300 ETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSS 364
            ||::..:::.|..||:|...|.|||.||..:     :||:|.:.|:|:.:..|.||||.:..:.:
  Fly   309 ETTAQVLTHTLLFLARNPKEQMKLREEIGTA-----ELTFEQISELPFTEACIHETLRIFSPVLA 368

  Fly   365 LTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFA---PDACRERH 426
            ..::.:|..|:.:.:|.. |.|..|..|.|||.|:|:||:.|.||..|:||||.   ..|.:.|.
  Fly   369 ARKVVTEPCELTNKNGVS-VKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRD 432

  Fly   427 PTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLI 481
            ...|.|||||||.|.|:||...|:|..|:.::|.|...:.|      |..|.|.|
  Fly   433 QGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNP------KTRKDNEI 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	136/483 (28%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	133/477 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	7	7.070