DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	143/498 - (28%)
Similarity:	241/498 - (48%)	Gaps:	67/498 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLF-----GHFFRLQSVHYSELLQETYDAFRG 64
            |:|:.:||..:..:|.:.|.||..||| :..|.:.|     ..|.|.:::.|.  :.:.|:.::.
  Fly     8 LVLVLTLLVLVYVFLTWNFNYWRKRGI-KTAPTWPFVGSFPSIFTRKRNIAYD--IDDIYEKYKD 69

  Fly    65 SAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHGDP------------LTANLFNLQ 117
            :..:.|.:....|..:|:..:.:..:...||      ||||.:.            |..|.|.|.
  Fly    70 TDNMVGVFTTRVPQLLVMCPEYIHKIYATDF------RSFHNNEWRNFVNKKTDMILGNNPFVLT 128

  Fly   118 GEEWRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAV-----LELHDLMARYTT 177
            |:||:..|:::.|..:..::|    .|..|:|.:...|.|.:..|..:     |:..||...|||
  Fly   129 GDEWKERRSEIMPALSPNRVK----AVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTT 189

  Fly   178 DVIGSCAFGTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILH--PD 240
            :|:..|..|....|..:......::.:|:|..|        |:..:.|.:..|...||..:  |.
  Fly   190 EVVSDCGLGVSAQSFTDTPTPLLKMIKRVFNTS--------FEFIFYSVVTNLWQKVRKFYSVPF 246

  Fly   241 ITK----FFNRIVRETVELR-ERENIRRNDFMDLLLDLRRQENGKGLTMEQMAAQAFVFFVAGFE 300
            ..|    ||..|:|..:.|| |:...:|:||::.:|.|:.:   |||..:.:......|.:.|||
  Fly   247 FNKETEVFFLDIIRRCITLRLEKPEQQRDDFLNYMLQLQEK---KGLHTDNILINTMTFILDGFE 308

  Fly   301 TSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSL 365
            |::..:::.:..|.:|.:.|.|:|.||..:     .||::.|.|:|:||..|.||||.:....:.
  Fly   309 TTALVLAHIMLMLGRNPEEQDKVRKEIGSA-----DLTFDQMSELPHLDACIYETLRLFSPQVAA 368

  Fly   366 TRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPD------ACRE 424
            .:|.:|.:|..:.: |..|.|:.|..|.|||.|:|:||:.|.:|..|:||||...      :.|:
  Fly   369 RKLVTEPFEFANKN-GRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRD 432

  Fly   425 RHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPP 467
            |  ..:|.||||||:|.|:||...|:|..|:.:||.|...:.|
  Fly   433 R--GVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNP 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	132/471 (28%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	132/467 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	6	6.070