DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	157/480 - (32%)
Similarity:	248/480 - (51%)	Gaps:	56/480 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKVAGTYVFLR 76
            |.|:...|.||..:||               |.|.....|.:              :.|.|...:
  Rat    44 LPFVGNILAYRHGFWE---------------FDRHCHKKYGD--------------IWGFYEGRQ 79

  Fly    77 PMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDPLTANLFNL-QGEEWRNLRTKLSPTFTSGKMKY 139
            |:..:.|.|::|.||::: ::.|.:||||....:......| :.|||:.|||.|||||||||:|.
  Rat    80 PILAITDPDIIKTVLVKECYSTFTNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKE 144

  Fly   140 MFGTVSTVAQQLGGTFDELV------GSQGAVLELHDLMARYTTDVIGSCAFGTECSSLREPQAE 198
            ||..::..|       |.||      ..:|..:.:.|:...|:.|||...:||....||..||..
  Rat   145 MFPIINQYA-------DLLVKNVKHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNP 202

  Fly   199 FRQVGRRIFR-NSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVELRERENIR 262
            |.|..:::.: |........:....:|:.:.: ...:.:...|:.|||...|....|.|.:|.::
  Rat   203 FVQKVKKLLKFNFLDPFFLSVILFPFLTPVFE-AFDITVFPKDVMKFFRTSVERMKENRMQEKVK 266

  Fly   263 -RNDFMDLLLDLRR---QENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKL 323
             |.||:.|:::.:.   :|:.:|||..::.||:..|..||:||:||.:|:||:.||.:.|:|:||
  Rat   267 QRLDFLQLMINSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKL 331

  Fly   324 RMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVLEK 388
            :.||:.::.....:||:.::||.|||..:.||||.:|....|.|:..:|.||      :.|.:.|
  Rat   332 QDEIDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEI------NGVFIPK 390

  Fly   389 GTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGRMQVKVG 453
            ||.|.:|..|:|.||:.:|||.||.||||........:|..:|.||:|||||||:||..|.:|:.
  Rat   391 GTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIA 455

  Fly   454 LITLLRRFRFSLPPGSPTQLKVTKR 478
            |:.:|:.|.|.|...:...||:.|:
  Rat   456 LVRVLQNFSFGLCKETQIPLKLRKK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	150/460 (33%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	157/480 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870