DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a16 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	534	Identity:	174/534 - (32%)
Similarity:	272/534 - (50%)	Gaps:	83/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TLLLLTSLLSFLLGYLRYRFTY--WELRGIPQLRPHFLFGHFFRLQSVHYSE-LLQETYDAFRGS 65
            |.|||.  :|.:|.||....|:  ::..|||...|..|.|:.     :.|.: |.:...:.::..
Human    11 TWLLLA--VSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV-----LSYRQGLWKFDTECYKKY 68

  Fly    66 AKVAGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDPLTANLFNL-QGEEWRNLRTKL 128
            .|:.|||....|:..:.|.|:::.||::: ::.|.:|||........:..:| :.|||:.:|:.|
Human    69 GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLL 133

  Fly   129 SPTFTSGKMKYMFGTVSTVAQQLGGTFDELV------GSQGAVLELHDLMARYTTDVIGSCAFGT 187
            ||||||||:|.||..::    |.|   |.||      ..:|..:.|.|:...|:.|||...:||.
Human   134 SPTFTSGKLKEMFPIIA----QYG---DVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191

  Fly   188 ECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFF------- 245
            ...||..||..|       ..::.:.:::......:||.         ||.|.:|..|
Human   192 NIDSLNNPQDPF-------VESTKKFLKFGFLDPLFLSI---------ILFPFLTPVFEALNVSL 240

  Fly   246 -------------NRIVRETVELRERENIRRNDFMDLLLD---LRRQENGKGLTMEQMAAQAFVF 294
                         ||:.:..:..:::   .|.||:.|::|   .:..|:.|.|:..::|||:.:|
Human   241 FPKDTINFLSKSVNRMKKSRLNDKQK---HRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302

  Fly   295 FVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKY 359
            ..||:||:||.:|:.|:|||.:.||||||:.||:..:......||:|:::|.|||..:.||||.:
Human   303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367

  Fly   360 PALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFA--PDAC 422
            |....|.|...:|.||      :.|.:.||:.|.||..|:|:||:.:.||.|||||||:  .|:.
Human   368 PVAIRLERTCKKDVEI------NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI 426

  Fly   423 RERHPTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQ--LKVTKRNLILLPS 485
               .|..:..||.|||||||:||..|.:|:.||.:|:.|.|.  |...||  ||:..:.| |.|.
Human   427 ---DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK--PCKETQIPLKLDTQGL-LQPE 485

  Fly   486 DGVRLQVDPVESRL 499
            ..:.|:||..:..|
Human   486 KPIVLKVDSRDGTL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	160/495 (32%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	160/495 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820