Protein Alignment Cyp6a16 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_001285631.1
• Gene: Cyp6a16 / 19836250
• FlyBaseID: FBgn0031726
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 162/511 - (31%)
• Similarity: 259/511 - (50%)
• Gaps: 44/511 - (8%)

  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKVA 69
            |||..||:...|...|....:.:| |||...|....|:....:..::: ...|.|..:|   ||.
Human    13 LLLAVSLILLYLYGTRTHGLFKKL-GIPGPTPLPFLGNALSFRKGYWT-FDMECYKKYR---KVW 72

  Fly    70 GTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDPLTANLFNL-QGEEWRNLRTKLSPTF 132
            |.|...:||..:.|.|::|.||::: ::.|.:||.|.......|..:: :.|||:.:|:.|||||
Human    73 GIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTF 137

  Fly   133 TSGKMKYMFGTVSTVAQQLGGTFDELV------GSQGAVLELHDLMARYTTDVIGSCAFGTECSS 191
            ||||:|.|   |..:||.    .|.||      ...|..:.|..:...|:.|||.|.:||....|
Human   138 TSGKLKEM---VPIIAQY----GDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195

  Fly   192 LREPQAEFRQVGRRIFR-NSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRIVRETVEL 255
            |..||..|.:..:::.| |........|....:|:.:.: .|.:.:....:..|..:.|::..|.
Human   196 LNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILE-ALNITVFPRKVISFLTKSVKQIKEG 259

  Fly   256 RERENIR-RNDFMDLLLDLRR---QENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFELAKN 316
            |.:|..: |.||:.|::|.:.   .|..|.|:..::.||:.:|..||:||:||.:|:.::|||.:
Human   260 RLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATH 324

  Fly   317 QDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGG 381
            .|||||::.||:..:......||:.::::.|||..:.||||.:|....|.|:..:|.||
Human   325 PDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI------ 383

  Fly   382 DPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIGLRFG 446
            :.:.:.||..|.||...:|:||:.:.||.:|.||||:........|..:..||.|||||||:||.
Human   384 NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448

  Fly   447 RMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDPV----ESR 498
            .:.:|:.|:.:|:.|.|.  |...||:.:..|      ..|:.|...|:    |||
Human   449 LVNMKLALVRVLQNFSFK--PCKETQIPLKLR------FGGLLLTEKPIVLKAESR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a16	NP_001285631.1	CYP6-like	64..489	CDD:410679	141/437 (32%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	144/449 (32%)