Protein Alignment PIG-Z and PIGZ

DIOPT Version :10

• Sequence 1: NP_001286840.1
• Gene: PIG-Z / 19835548
• FlyBaseID: FBgn0266438
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_016862730.1
• Gene: PIGZ / 80235
• HGNCID: 30596
• Length: 644
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 195/651 - (29%)
• Similarity: 269/651 - (41%)
• Gaps: 156/651 - (23%)

  Fly     1 MRLTTLWQNRSPGDRHLSTYFCFAAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWE 65
            |.:..||...|             .:|:|...:||.|||||||||||.|||..|...::..|.||
Human    97 MAVRVLWGGLS-------------LLRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWE 148

  Fly    66 FNNSLPVRSIVLP-------FALLRI-----PWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIY 118
            |..|...||::.|       |.|||:     ||.               .|:..||.:|.|||:.
Human   149 FYPSSSCRSVLFPLLISGSTFWLLRLWEELGPWP---------------GLVSGYALLVGPRLLL 198

  Fly   119 TLISFSNDYCLFRICRLYGLRFEIRLLAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVSECMLR 183
            |.:||:.|..::.:....|......|..:..|::.|||.||||||::|..:.:|||.|||..:..
Human   199 TALSFALDGAVYHLAPPMGADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTW 263

  Fly   184 TNTVVYKKEFLEEKYDKAESISERVRIWKLKNSLPAHNLQHLMAMSTICVAGVFNRPTFLLFGAP 248
            ..|   :||         .:...|.|.|.|               ..|..||.|||||||.|...
Human   264 GPT---RKE---------PAPGPRWRSWLL---------------GGIVAAGFFNRPTFLAFAVV 301

  Fly   249 MVFFWLLRGM---GTRSITFRDFNLRIALFCL--CALPALVLFIFCDSLYYQHLTLGELHMMHLS 308
            .::.|..||.   |.:|:|      |.||..|  .||.|.| |:..||.|:.......
Human   302 PLYLWGTRGATNPGLKSLT------REALVLLPGAALTAAV-FVATDSWYFSSPATSR------- 352

  Fly   309 IDNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMPMLFNVLALASLGAFAQLLLRFFRAEYQ 373
              |.|.||.||:..||:....|.||.|....||.||..:||.||...:|.|..|.|....:|..|
Human   353 --NLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQRLQVGLQASAQ 415

  Fly   374 V-LPRFQSIVSLMSG-------AIFVPLFFLSLINHQEPRFLLPVTFPLILLHAPKLITGFSAKY 430
            : |.|.....||:|.       ..|:||..||..:|||.|||:|:..||:||.:|:     :...
Human   416 MGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFLIPLLVPLVLLCSPQ-----TQPV 475

  Fly   431 PFQKDHPLLRLFYDKLLSSKASGPYLLKIWYVSNVALTLFFGFIHQAGVYP---LAADISHVIAT 492
            |::                   |..:|     .|....|.||.:||.|:.|   ....:.|....
Human   476 PWK-------------------GTVVL-----FNALGALLFGCLHQGGLVPGLEYLEQVVHAPVL 516

  Fly   493 KPAATHVHLITSHIYSLPLHLINIPSSRVLHFNRLTHQRYRRPRDFYMYEYGGLPLDSLLQKVKL 557
            ....||..|:.:|.|..|.||:::|.             ...|.:  :.:.||....:|.|.:|.
Human   517 PSTPTHYTLLFTHTYMPPRHLLHLPG-------------LGAPVE--VVDMGGTEDWALCQTLKS 566

  Fly   558 IS--GSCEVKKSGPSRRRYKLYLAIPASLSADLHEALVHSNASSYLNFELLKVFYPHLSTEAFPH 620
            .:  .:|:| ..||...|  |::..|.:.     ...|...:..:.|..||   :|||:.|..|.
Human   567 FTRQPACQV-AGGPWLCR--LFVVTPGTT-----RRAVEKCSFPFKNETLL---FPHLTLEDPPA 620

  Fly   621 L 621
            |
Human   621 L 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-Z	NP_001286840.1	Glyco_transf_22	18..541	CDD:281842	169/550 (31%)
PIGZ	XP_016862730.1	PMT_2	109..>456	CDD:473917	138/404 (34%)