DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45065 and Gld

DIOPT Version :9

Sequence 1:	NP_001285251.1	Gene:	CG45065 / 19835504	FlyBaseID:	FBgn0266435	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	245/589 - (41%)
Similarity:	352/589 - (59%)	Gaps:	53/589 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 QYDFVVIGGGSAGAVVANRLSEVRNWTVLLLEAGGDETEISDVPALAGYLQL--TELDWKYQTTP 105
            :|||:||||||||:|||:|||||..|.|||:||||||...:.:|::  :|..  :::|::|.|.|
  Fly    64 EYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSM--FLNFIGSDIDYRYNTEP 126

  Fly   106 SSTRQYCQAMKGDRCFWPRGKVLGGSSVLNAMVYVRGSKNDYNHWASLGNPGWDYDSMLKYFLKS 170
            ..  ..|.:....||:|||||||||:||||.|:||||::.||:.||:.|||||.|:.:|.:|.||
  Fly   127 EP--MACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGWAYNDVLPFFKKS 189

  Fly   171 EDVRNPYLAKTPYHETGGYLTVQEAPWRTPLSIAFLQAGIEMGYENRDINGAQQTGFMLTQSTIR 235
            ||..:.....|.||..||.|.|.:.|:..|||.|.|:||.|:|:...|:||...||||:.|.|.|
  Fly   190 EDNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHDLNGQNSTGFMIAQMTAR 254

  Fly   236 RGARCSTGKAFIRPVRQRKNFDVLLHAEATRILFDKQ-KRAIGVEYM-RGGRKNVVFVRREVIAS 298
            .|.|.|:.:||:||.|.|.|..:||:..||:||.... |..:|||.. :.|....:.|::||:.|
  Fly   255 NGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVLGVEVSDQFGSTRKILVKKEVVLS 319

  Fly   299 AGALNTPKLLMLSGVGPAEHLQEHNIPVISDLP-VGNNMQDHVGLGGLTFVVDAPLTVTRNRFQT 362
            |||:|:|.:|:||||||.:.||:.|:..:.:|| ||.|:.:||......|:.||         .|
  Fly   320 AGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNFFIDDA---------DT 375

  Fly   363 IPV----SMEYILRERGPMTFSGVEGV-AFLNTKYQDPSVDWPDVQFHFCPSSINSDGG------ 416
            .|:    :|||:|...|.|:.:|:..| |.|.|:|.| |.:.||:|.:|        ||
  Fly   376 APLNWATAMEYLLFRDGLMSGTGISDVTAKLATRYAD-SPERPDLQLYF--------GGYLASCA 431

  Fly   417 --EQIRKILNLRDGFYNTVYKPLQHSETWSILPLLLRPKSTGWVRLNSRNPQHQPKIIPNYFAHQ 479
              .|:.::|:             .:|.:..|.|.:|.|:|.|::.|.|.:|...|:|:.||..|:
  Fly   432 RTGQVGELLS-------------NNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHE 483

  Fly   480 EDIDVLVEGIKLAINVSNTQAFQRFGSRLHNIPLPGCRHLPFQSNEYWACCIKEFTFTIYHPAGT 544
            :|:..||||||..|.:|.|...:::|.||....:.||....|.|:.||.|.:::.|....|.||:
  Fly   484 QDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTGPENHQAGS 548

  Fly   545 CRMGPSWDVTAVVDPRLRVYGVSGVRVVDASIMPTIVNGNPNAPVIAIGEKASDLIKEDWGVRRA 609
            |:||||.|..|||:..|||:|:.|:||:|.||||.:.:||.:||.:.|.||.:.|:|..||.:..
  Fly   549 CKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAWGAKVX 613

  Fly   610 HTSA 613
            ...|
  Fly   614 RVDA 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45065	NP_001285251.1	PRK02106	42..601	CDD:235000	241/575 (42%)
		NADB_Rossmann	117..339	CDD:304358	108/224 (48%)
		GMC_oxred_C	452..596	CDD:282984	62/143 (43%)
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	23/30 (77%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	240/571 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	8	7.960