DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45065 and CG9503

DIOPT Version :9

Sequence 1:	NP_001285251.1	Gene:	CG45065 / 19835504	FlyBaseID:	FBgn0266435	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_572987.1	Gene:	CG9503 / 32424	FlyBaseID:	FBgn0030598	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	603	Identity:	332/603 - (55%)
Similarity:	443/603 - (73%)	Gaps:	7/603 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TSLLGMIPLLAIGMNFYRYQS-VDPENKVQE--PTVIRRQYDFVVIGGGSAGAVVANRLSEVRNW 68
            ||....||:|...:.:::|:. :|||:|..:  ...|...|||:|||.|||||||||||:||.||
  Fly    20 TSNSWFIPMLMAAVAYFQYEEIIDPESKPSDVGGDDILDHYDFIVIGAGSAGAVVANRLTEVENW 84

  Fly    69 TVLLLEAGGDETEISDVPALAGYLQLTELDWKYQTTPSSTRQYCQAMKGDRCFWPRGKVLGGSSV 133
            .||||||||||||::|||.:||||||:::||:|:|.||.|.  |.||:|.||.||||||||||||
  Fly    85 NVLLLEAGGDETELTDVPLMAGYLQLSKIDWQYKTEPSGTS--CLAMQGGRCNWPRGKVLGGSSV 147

  Fly   134 LNAMVYVRGSKNDYNHWASLGNPGWDYDSMLKYFLKSEDVRNPYLAKTPYHETGGYLTVQEAPWR 198
            ||.|:|:||||:||::|.::|||.|.|...|.||.||||..|.|||.||||.|||||||.|||:.
  Fly   148 LNYMLYLRGSKHDYDNWEAMGNPSWSYRDALYYFKKSEDNTNQYLANTPYHATGGYLTVGEAPYH 212

  Fly   199 TPLSIAFLQAGIEMGYENRDINGAQQTGFMLTQSTIRRGARCSTGKAFIRPVRQRKNFDVLLHAE 263
            |||:.:|::||:||||||||:||.:.||||:.|.|.|||:||||.|||:||.|.|.|..:.:::.
  Fly   213 TPLAASFVEAGVEMGYENRDLNGEKMTGFMIAQGTTRRGSRCSTSKAFLRPARLRPNLHISMNSH 277

  Fly   264 ATRILFDK-QKRAIGVEYMRGGRKNVVFVRREVIASAGALNTPKLLMLSGVGPAEHLQEHNIPVI 327
            .|||:.|. .|.|.|||:::..:...|...:||:.|.|::|:|:|||||||||.:.|.:|.||:|
  Fly   278 VTRIMIDPVTKLAFGVEFVKDQKLYHVRATKEVVLSGGSVNSPQLLMLSGVGPRKELAKHRIPLI 342

  Fly   328 SDLPVGNNMQDHVGLGGLTFVVDAPLTVTRNRFQTIPVSMEYILRERGPMT-FSGVEGVAFLNTK 391
            .:|.||.|:|||:|||||||:|:.|:::..|||.|:...::|.:..:||:| ..||||:|::|||
  Fly   343 KELSVGENLQDHIGLGGLTFLVNQPVSIVENRFHTMSTVLQYAVFGQGPLTILGGVEGLAYVNTK 407

  Fly   392 YQDPSVDWPDVQFHFCPSSINSDGGEQIRKILNLRDGFYNTVYKPLQHSETWSILPLLLRPKSTG 456
            |.:.|:||||::|||...|.|||||.|:||...|.|.||..|::|:.:.:.|||:|:||||:|.|
  Fly   408 YANSSLDWPDIEFHFVSGSTNSDGGSQLRKAHGLTDAFYRAVFEPINNRDAWSIIPMLLRPRSVG 472

  Fly   457 WVRLNSRNPQHQPKIIPNYFAHQEDIDVLVEGIKLAINVSNTQAFQRFGSRLHNIPLPGCRHLPF 521
            .:||.|.||...|.|.|||.....|:..|:||:|:|:.:|.|:|.||||||:.:|..|||..:|.
  Fly   473 NIRLRSGNPFDYPYIFPNYLTDDFDMKTLIEGVKIAVALSRTKAMQRFGSRISSIRWPGCEQVPL 537

  Fly   522 QSNEYWACCIKEFTFTIYHPAGTCRMGPSWDVTAVVDPRLRVYGVSGVRVVDASIMPTIVNGNPN 586
            .::.:|.|.::.:|.|||||.|||:|||.||..||||.:|||||:.|:||:||||||.:|:.|.|
  Fly   538 FTDAFWECMVRRYTSTIYHPVGTCKMGPYWDKDAVVDAKLRVYGIRGLRVIDASIMPKLVSANTN 602

  Fly   587 APVIAIGEKASDLIKEDW 604
            ||||.|.||.||:|||.|
  Fly   603 APVIMIAEKGSDMIKEFW 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45065	NP_001285251.1	PRK02106	42..601	CDD:235000	317/560 (57%)
		NADB_Rossmann	117..339	CDD:304358	128/222 (58%)
		GMC_oxred_C	452..596	CDD:282984	76/143 (53%)
CG9503	NP_572987.1	PRK02106	59..617	CDD:235000	317/559 (57%)
		NADB_Rossmann	122..354	CDD:304358	133/233 (57%)
		GMC_oxred_C	468..611	CDD:282984	75/142 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	8	8.060