Protein Alignment CG45065 and Chdh

DIOPT Version :9

• Sequence 1: NP_001285251.1
• Gene: CG45065 / 19835504
• FlyBaseID: FBgn0266435
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_001129712.1
• Gene: Chdh / 218865
• MGIID: 1860776
• Length: 596
• Species: Mus musculus
• Alignment Length: 581
• Identity: 220/581 - (37%)
• Similarity: 314/581 - (54%)
• Gaps: 60/581 - (10%)

  Fly    38 TVIRRQYDFVVIGGGSAGAVVANRLSEVRNWTVLLLEAGGDET---------EISDVPALAGYLQ 93
            :|.:.:|.|||:|.||||.|:|:||:|..|..|||||||..:.         :|....||...|.
Mouse    37 SVGKDEYTFVVVGAGSAGCVLASRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVSNLC 101

  Fly    94 LTELDWKYQTTPSSTRQYCQAMKGDRCFWPRGKVLGGSSVLNAMVYVRGSKNDYNHWASLGNPGW 158
            ..:.:|.|.|.|.      ..|.....:||||:|.||||.||||||:||...|||.|...|..||
Mouse   102 DDKYNWYYHTEPQ------PGMDSRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWHREGAEGW 160

  Fly   159 DYDSMLKYFLKSEDVRNPYLAKTPYHETGGYLTVQEAPWRTPLSIAFLQAGIEMGYE-NRDINGA 222
            ||...|.||.|::   ...|....|....|.|.|.......||..|||||..:.||. ..|:||.
Mouse   161 DYAHCLPYFRKAQ---RHELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPFTEDMNGF 222

  Fly   223 QQTGFMLTQSTIRRGARCSTGKAFIRPVRQRKNFDVLLHAEATRILFDKQKRAIGVEYMRGGRKN 287
            ||.||.....|:.:|.|.||..|::.||..|.|....:....:|:||: ..||:||||::.|:::
Mouse   223 QQEGFGWMDMTVHQGKRWSTACAYLHPVLSRPNLRAEVQTLVSRVLFE-GTRAVGVEYIKDGQRH 286

  Fly   288 VVFVRREVIASAGALNTPKLLMLSGVGPAEHLQEHNIPVISDLP-VGNNMQDHVGLGGLTFVVDA 351
            ..:|.||||.|.||:|:|:||||||||.|:.|::.:|||:..|| ||.|:|||:.:    :|..|
Mouse   287 KAYVSREVILSGGAINSPQLLMLSGVGNADDLRKLDIPVVCHLPGVGQNLQDHLEV----YVQQA 347

  Fly   352 ---PLTV--TRNRFQTIPVSMEYILRERGPMTFSGVEGVAFLNTKYQDPSVDWPDVQFHFCPSSI 411
               |:|:  .:...:.:.:.:|::....|....:.:|...|:.::   |.|..||:||||.||.:
Mouse   348 CTQPITLHSAQKPLRKVCIGLEWLWSYTGDGATAHLETGGFIRSR---PGVPHPDIQFHFLPSQV 409

  Fly   412 NSDGGEQIRKILNLRDGFYNTVYKPLQHSETWSILPLLLRPKSTGWVRLNSRNPQHQPKIIPNYF 476
            ...|                  .||.| .|.:.:....:|..|.||::|.|.||:..|.|.|||.
Mouse   410 IDHG------------------RKPTQ-QEAYQVHVGTMRATSVGWLKLRSANPRDHPVIHPNYL 455

  Fly   477 AHQEDIDVLVEGIKLAINVSNTQAFQRF-GSRLHNIPLPGCRHLPFQSNEYWACCIKEFTFTIYH 540
            :.:.|::...:.::|:..:...:|...| |..|.    || .|:  ||::.....::....:.||
Mouse   456 STETDVEDFRQCVRLSREIFAQEALAPFRGKELQ----PG-SHV--QSDKEIDAFVRAKADSAYH 513

  Fly   541 PAGTCRMGPSWDVTAVVDPRLRVYGVSGVRVVDASIMPTIVNGNPNAPVIAIGEKASDLIK 601
            |:.||:||.|.|.|||||.:.:|.||..:|||||||||::|:||.|||.:.|.|||:|:||
Mouse   514 PSCTCKMGRSSDPTAVVDAQTKVIGVENLRVVDASIMPSVVSGNLNAPTVMIAEKAADIIK 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45065	NP_001285251.1	PRK02106	42..601	CDD:235000	217/575 (38%)
		NADB_Rossmann	117..339	CDD:304358	100/223 (45%)
		GMC_oxred_C	452..596	CDD:282984	57/144 (40%)
Chdh	NP_001129712.1	PRK02106	42..588	CDD:235000	219/576 (38%)
		NAD_binding_8	47..>76	CDD:290186	18/28 (64%)
		GMC_oxred_N	118..341	CDD:279121	102/226 (45%)
		GMC_oxred_C	432..569	CDD:282984	57/143 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm42468
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3702
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900