DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45063 and Atp2c2

DIOPT Version :9

Sequence 1:	NP_001286728.1	Gene:	CG45063 / 19835490	FlyBaseID:	FBgn0266433	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_081198.1	Gene:	Atp2c2 / 69047	MGIID:	1916297	Length:	944	Species:	Mus musculus

Alignment Length:	197	Identity:	52/197 - (26%)
Similarity:	87/197 - (44%)	Gaps:	31/197 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ELCARLEANVSQGLTSEAAGRKLARNG------KNVLPLPTKLELRPWIFLKSCFSILGIIILLS 110
            ||......::..||:..|..::...:|      .|..|:..|       :|....:.|.:::|.|
Mouse    62 ELARAFHVDLDSGLSEFAVAQRRLVHGWNEFVTDNAEPVWKK-------YLDQFRNPLILLLLGS 119

  Fly   111 SIASFAMYYLFATKTPDNGKVDPEFLVAGIILLVTFFLAGLTVQMQGDDDEDMLIAFDELMPMYC 175
            |:.|      ..||..:    |...:...::::||   .|.   :|....|..|....:|:|..|
Mouse   120 SVVS------VLTKEYE----DAVSIALAVLIVVT---VGF---IQEYRSEKSLEELTKLVPPEC 168

  Fly   176 TVIRDGEKEVIRTQDLVPGDTLPIKYGQRLPADMRFFSTTGLELNNVALTGHSKPMHIT--PLAN 238
            ..:|||:...:..:||||||.:.:..|.|:|||:|....|.|.::..:.||..:|...|  |||:
Mouse   169 NCLRDGKLRHMLARDLVPGDIVSLSMGDRIPADIRLTEVTDLLVDESSFTGEVEPCGKTDSPLAD 233

  Fly   239 EG 240
            .|
Mouse   234 GG 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45063	NP_001286728.1	Cation_ATPase_N	46..117	CDD:214842	15/70 (21%)
CG45063	NP_001286728.1	E1-E2_ATPase	140..>230	CDD:278548	28/89 (31%)
Atp2c2	NP_081198.1	ATPase-IIA2_Ca	54..929	CDD:130585	52/197 (26%)
		Cation_ATPase_N	61..123	CDD:279080	14/67 (21%)
		Interaction with ORAI1. /evidence=ECO:0000250\|UniProtKB:O75185	69..93		4/23 (17%)
		E1-E2_ATPase	135..366	CDD:278548	34/107 (32%)
		Cation_ATPase	439..521	CDD:289987
		COG4087	584..707	CDD:226572
		Cation_ATPase_C	754..927	CDD:279079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831021
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930