Protein Alignment CG45063 and ATP7A

DIOPT Version :10

• Sequence 1: NP_001286728.1
• Gene: CG45063 / 19835490
• FlyBaseID: FBgn0266433
• Length: 252
• Species: Drosophila melanogaster
• Sequence 2: NP_000043.4
• Gene: ATP7A / 538
• HGNCID: 869
• Length: 1500
• Species: Homo sapiens
• Alignment Length: 187
• Identity: 33/187 - (17%)
• Similarity: 60/187 - (32%)
• Gaps: 74/187 - (39%)

  Fly    93 WIF-------LKSCFSILGIIILLSSIASF---------AMYYLFATKTPDNGKVDPEFLVAGII 141
            |.|       ||...:.:.::|:|::..:|         |||        :..||:|
Human   729 WYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMY--------ERAKVNP-------- 777

  Fly   142 LLVTFFLAGLTVQMQGDDDEDMLIAF----------------------DELMPMYCTVIRDGEKE 184
              :|||           |...||..|                      ..|.....|::......
Human   778 --ITFF-----------DTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDN 829

  Fly   185 VIRTQDLVP------GDTLPIKYGQRLPADMRFFSTTGLELNNVALTGHSKPMHITP 235
            ::.:::.|.      ||.:.:..|.:.|.|.|......: ::...:||.:.|:...|
Human   830 ILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM-VDESLITGEAMPVAKKP 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45063	NP_001286728.1	ATPase-IIC_X-K	21..>230	CDD:273445	31/180 (17%)
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..443	CDD:238219
		HMA	492..554	CDD:238219
		HMA	567..630	CDD:238219
		P-type_ATPase_Cu-like	652..1388	CDD:319783	33/187 (18%)
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1487..1488