DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45063 and ATP7A

DIOPT Version :9

Sequence 1:	NP_001286728.1	Gene:	CG45063 / 19835490	FlyBaseID:	FBgn0266433	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens

Alignment Length:	187	Identity:	33/187 - (17%)
Similarity:	60/187 - (32%)	Gaps:	74/187 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 WIF-------LKSCFSILGIIILLSSIASF---------AMYYLFATKTPDNGKVDPEFLVAGII 141
            |.|       ||...:.:.::|:|::..:|         |||        :..||:|
Human   729 WYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMY--------ERAKVNP-------- 777

  Fly   142 LLVTFFLAGLTVQMQGDDDEDMLIAF----------------------DELMPMYCTVIRDGEKE 184
              :|||           |...||..|                      ..|.....|::......
Human   778 --ITFF-----------DTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDN 829

  Fly   185 VIRTQDLVP------GDTLPIKYGQRLPADMRFFSTTGLELNNVALTGHSKPMHITP 235
            ::.:::.|.      ||.:.:..|.:.|.|.|......: ::...:||.:.|:...|
Human   830 ILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM-VDESLITGEAMPVAKKP 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45063	NP_001286728.1	Cation_ATPase_N	46..117	CDD:214842	7/39 (18%)
CG45063	NP_001286728.1	E1-E2_ATPase	140..>230	CDD:278548	18/117 (15%)
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..443	CDD:238219
		HMA	492..554	CDD:238219
		HMA	567..630	CDD:238219
		P-type_ATPase_Cu-like	652..1388	CDD:319783	33/187 (18%)
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1487..1488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930