DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45063 and ATP4A

DIOPT Version :9

Sequence 1:	NP_001286728.1	Gene:	CG45063 / 19835490	FlyBaseID:	FBgn0266433	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_000695.2	Gene:	ATP4A / 495	HGNCID:	819	Length:	1035	Species:	Homo sapiens

Alignment Length:	231	Identity:	61/231 - (26%)
Similarity:	105/231 - (45%)	Gaps:	21/231 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SRRKKK-----EERESLQQTENELWLEYFSPYLHIWPFHELCARLEANVSQGLTSEAAGRKLARN 77
            |::||.     :.:|.|:..:.|:.:..     |.....||..:.:.:.::||::..|...|.|:
Human    27 SKKKKAGGGGGKRKEKLENMKKEMEIND-----HQLSVAELEQKYQTSATKGLSASLAAELLLRD 86

  Fly    78 GKNVLPLPTKLELRPWIFLKSCFSILGIIILLSSIASFAMYYLFATKTPDNGKVDPEFLVAGIIL 142
            |.|.|..|....    .::|....:.|.:..|..:|:......||.:..:......:.|...|.|
Human    87 GPNALRPPRGTP----EYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIAL 147

  Fly   143 LVTFFLAGLTVQMQGDDDEDMLIAFDELMPMYCTVIRDGEKEVIRTQDLVPGDTLPIKYGQRLPA 207
            :....:.|.....|.....:::.:|..|:|...||||||:|..|....||.||.:.:|.|.|:||
Human   148 IAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPA 212

  Fly   208 DMRFFSTTGLELNNVALTGHSKPM-------HITPL 236
            |:|..:..|.:::|.:|||.|:|.       |.:||
Human   213 DIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPL 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45063	NP_001286728.1	Cation_ATPase_N	46..117	CDD:214842	16/70 (23%)
CG45063	NP_001286728.1	E1-E2_ATPase	140..>230	CDD:278548	32/89 (36%)
ATP4A	NP_000695.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		3/13 (23%)
		H-K_ATPase_N	2..>22	CDD:312544
		ATPase-IIC_X-K	43..1035	CDD:273445	57/215 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141068
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840