DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45063 and Atp13a4

DIOPT Version :9

Sequence 1:	NP_001286728.1	Gene:	CG45063 / 19835490	FlyBaseID:	FBgn0266433	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_001158084.1	Gene:	Atp13a4 / 224079	MGIID:	1924456	Length:	1193	Species:	Mus musculus

Alignment Length:	192	Identity:	46/192 - (23%)
Similarity:	77/192 - (40%)	Gaps:	34/192 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 ARLEANVSQGLTSEAAGRKLARNGKNVLPLPTKLELRP-W-IFLKSCFSILGIIILLSSIASFAM 117
            |::......|||||....:....|.|.:    .:|:.| | :.:|...:...|..|.|....|:.
Mouse   161 AKIHQKFGLGLTSEEQEIRRLICGPNAI----DVEITPIWKLLIKEVLNPFYIFQLFSVCLWFSE 221

  Fly   118 YYLFATKTPDNGKVDPEFLVAGIILLVTFFLAGLTVQMQGDDDEDMLIAFDELMPMYCTVI---- 178
            .|             .|:.:|  |:|::.....|||.    |.....:....|:..:.::.
Mouse   222 DY-------------KEYALA--IILMSVISIALTVY----DLRQQSVKLHHLVESHNSITVSVY 267

  Fly   179 -RDGEKEVIRTQDLVPGDTLPIKYGQR--LPADMRFFSTTGLELNNVALTGHSKPMHITPLA 237
             |....:.:.::.|||||.| |..|.|  :|.|......:.: ::...|||.|.|:..|||:
Mouse   268 ERKAGAQDLESRLLVPGDLL-ILTGSRVQMPCDAILIDGSCV-VDEGMLTGESIPVTKTPLS 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45063	NP_001286728.1	Cation_ATPase_N	46..117	CDD:214842	16/63 (25%)
CG45063	NP_001286728.1	E1-E2_ATPase	140..>230	CDD:278548	23/96 (24%)
Atp13a4	NP_001158084.1	P-ATPase-V	18..1115	CDD:273738	46/192 (24%)
		P5-ATPase	18..137	CDD:289194
		Cation_ATPase_N	<170..218	CDD:279080	14/51 (27%)
		E1-E2_ATPase	228..472	CDD:278548	28/108 (26%)
		Cation_ATPase	<596..635	CDD:289987
		COG4087	<821..>870	CDD:226572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930