Protein Alignment CG45062 and ATP2C2

DIOPT Version :9

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001273456.2
• Gene: ATP2C2 / 9914
• HGNCID: 29103
• Length: 975
• Species: Homo sapiens
• Alignment Length: 722
• Identity: 155/722 - (21%)
• Similarity: 294/722 - (40%)
• Gaps: 180/722 - (24%)

  Fly    12 SNMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFK-----ERSRSRSQKHQKQISYYMLLVA- 70
            ||:....|....|.|..|.:..|.:::.|.:    ||     |..::..||...::...:.|.:
Human   243 SNIVFMGTLVQYGRGQGVVIGTGESSQFGEV----FKMMQAEETPKTPLQKSMDRLGKQLTLFSF 303

  Fly    71 -IVCFILLFLTTGFEHGH---IVYEVNLSLLIGLTPVYLPFI----LYWGLRRTRKEMGRKQCHV 127
             |:..|:|.   |:..|.   .::.:.:||.:...|..||.:    |..|:.|    |.:|:..|
Human   304 GIIGLIMLI---GWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLR----MAKKRVIV 361

  Fly   128 RNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGL-LSVDNLDVSAQ-------SPRFI-- 182
            :.|....|||..:|:.||..||:|...|.|:::....|| ..|..:....|       |...|
Human   362 KKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKE 426

  Fly   183 -------ELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDL--LRHDHE 238
                   :|:.|..:.|:|||....:    |.:...|.::.:|:         .:||  :::.:.
Human   427 FSNVSVGKLVEAGCVANNAVIRKNAV----MGQPTEGALMALAM---------KMDLSDIKNSYI 478

  Fly   239 KVANKHYNSEDK---VQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQE 300
            :.....::||.|   |:.:: :|.|.:.    :..|||..|.|||.|:.:......|||..|.:.
Human   479 RKKEIPFSSEQKWMAVKCSL-KTEDQED----IYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRS 538

  Fly   301 IILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIA 365
            ..|.....:...|..|.|.|                 :|.|.|.             |.|||::.
Human   539 FCLQEEKRMGSLGLRVLALA-----------------SGPELGR-------------LTFLGLVG 573

  Fly   366 TYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV 430
            ..:|||..:.:||.....:|:.:.::|....:.|.|:..::|:.   :...||::.:.:    :.
Human   574 IIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLC---NGKLQAMSGEEV----DS 631

  Fly   431 VDMSQYADE----------KPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVI 485
            |:..:.||.          .|:|:.:                        |..|.:..||:|::.
Human   632 VEKGELADRVGKVSVFFRTSPKHKLK------------------------IIKALQESGAIVAMT 672

  Fly   486 GGTLHDTPAMRSSHVGVA--KYGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYC 548
            |..::|..|::|:.:|:|  :.|:.|..|| |::||:|..|:.:::.|.:.:.:|.|:|..:.:.
Human   673 GDGVNDAVALKSADIGIAMGQTGTDVSKEA-ANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQ 736

  Fly   549 LATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPA------------------------- 588
            |:|:|..:.:.....:..:|..::.|..|.:..:::..||
Human   737 LSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKTEVCCTAVRLGVEGRGEST 801

  Fly   589 ----LTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVGTIEAAAVFM--TYFVFM----AD 643
                ..|..||.:::...|.|:...|.:|:..|      ::..:.:||:.:  |.|:|.    .|
Human   802 WAGRAGLGVEPVDKDAFRQPPRSVRDTILSRAL------ILKILMSAAIIISGTLFIFWKEMPED 860

  Fly   644 KGFLPRT 650
            :...|||
Human   861 RASTPRT 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	30/132 (23%)
		Cation_ATPase	190..284	CDD:289987	23/98 (23%)
		Cation_ATPase_C	582..777	CDD:295563	19/104 (18%)
ATP2C2	NP_001273456.2	ATPase-IIA2_Ca	55..960	CDD:130585	155/722 (21%)
		Cation_ATPase_N	63..125	CDD:279080
		E1-E2_ATPase	149..368	CDD:278548	31/135 (23%)
		Cation_ATPase	441..523	CDD:289987	23/99 (23%)
		COG4087	<625..709	CDD:226572	23/112 (21%)
		Cation_ATPase_C	756..957	CDD:279079	22/118 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141069
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840