Protein Alignment CG45062 and ATP2C2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001273456.2
• Gene: ATP2C2 / 9914
• HGNCID: 29103
• Length: 975
• Species: Homo sapiens
• Alignment Length: 722
• Identity: 155/722 - (21%)
• Similarity: 294/722 - (40%)
• Gaps: 180/722 - (24%)

  Fly    12 SNMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFK-----ERSRSRSQKHQKQISYYMLLVA- 70
            ||:....|....|.|..|.:..|.:::.|.:    ||     |..::..||...::...:.|.:
Human   243 SNIVFMGTLVQYGRGQGVVIGTGESSQFGEV----FKMMQAEETPKTPLQKSMDRLGKQLTLFSF 303

  Fly    71 -IVCFILLFLTTGFEHGH---IVYEVNLSLLIGLTPVYLPFI----LYWGLRRTRKEMGRKQCHV 127
             |:..|:|.   |:..|.   .::.:.:||.:...|..||.:    |..|:.|    |.:|:..|
Human   304 GIIGLIMLI---GWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLR----MAKKRVIV 361

  Fly   128 RNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGL-LSVDNLDVSAQ-------SPRFI-- 182
            :.|....|||..:|:.||..||:|...|.|:::....|| ..|..:....|       |...|
Human   362 KKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKE 426

  Fly   183 -------ELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDL--LRHDHE 238
                   :|:.|..:.|:|||....:    |.:...|.::.:|:         .:||  :::.:.
Human   427 FSNVSVGKLVEAGCVANNAVIRKNAV----MGQPTEGALMALAM---------KMDLSDIKNSYI 478

  Fly   239 KVANKHYNSEDK---VQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQE 300
            :.....::||.|   |:.:: :|.|.:.    :..|||..|.|||.|:.:......|||..|.:.
Human   479 RKKEIPFSSEQKWMAVKCSL-KTEDQED----IYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRS 538

  Fly   301 IILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIA 365
            ..|.....:...|..|.|.|                 :|.|.|.             |.|||::.
Human   539 FCLQEEKRMGSLGLRVLALA-----------------SGPELGR-------------LTFLGLVG 573

  Fly   366 TYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV 430
            ..:|||..:.:||.....:|:.:.::|....:.|.|:..::|:.   :...||::.:.:    :.
Human   574 IIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLC---NGKLQAMSGEEV----DS 631

  Fly   431 VDMSQYADE----------KPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVI 485
            |:..:.||.          .|:|:.:                        |..|.:..||:|::.
Human   632 VEKGELADRVGKVSVFFRTSPKHKLK------------------------IIKALQESGAIVAMT 672

  Fly   486 GGTLHDTPAMRSSHVGVA--KYGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYC 548
            |..::|..|::|:.:|:|  :.|:.|..|| |::||:|..|:.:::.|.:.:.:|.|:|..:.:.
Human   673 GDGVNDAVALKSADIGIAMGQTGTDVSKEA-ANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQ 736

  Fly   549 LATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPA------------------------- 588
            |:|:|..:.:.....:..:|..::.|..|.:..:::..||
Human   737 LSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKTEVCCTAVRLGVEGRGEST 801

  Fly   589 ----LTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVGTIEAAAVFM--TYFVFM----AD 643
                ..|..||.:::...|.|:...|.:|:..|      ::..:.:||:.:  |.|:|.    .|
Human   802 WAGRAGLGVEPVDKDAFRQPPRSVRDTILSRAL------ILKILMSAAIIISGTLFIFWKEMPED 860

  Fly   644 KGFLPRT 650
            :...|||
Human   861 RASTPRT 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	154/721 (21%)
ATP2C2	NP_001273456.2	P-type_ATPase_SPCA	85..956	CDD:319779	155/722 (21%)