Protein Alignment CG45062 and Atp1a2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_848492.1
• Gene: Atp1a2 / 98660
• MGIID: 88106
• Length: 1020
• Species: Mus musculus
• Alignment Length: 847
• Identity: 255/847 - (30%)
• Similarity: 419/847 - (49%)
• Gaps: 130/847 - (15%)

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQ----KQISYYMLL---VA 70
            |:....|:.:.|....:.:|.|..|.:|.:..|.      |..:..|    .:|.:::.|   ||
Mouse   239 NICFFSTNCVEGTARGIVIATGDRTVMGRIATLA------SGLEVGQTPIAMEIEHFIQLITGVA 297

  Fly    71 I---VCFILLFLTTGFEH--------GHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQ 124
            :   |.|.:|.|..|:..        |.||..|...||..:|..         |..|.|.|.||.
Mouse   298 VFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKN 353

  Fly   125 CHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIE 183
            |.|:||.|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:      ...:||.:..
Mouse   354 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTA 418

  Fly   184 LIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSE 248
            |.|.:.|||.||...|...:...::|..|:..:.||||...:...|:..:|..:.|||...:||.
Mouse   419 LSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNST 483

  Fly   249 DKVQVTVHRTRDA-DGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQ------------- 299
            :|.|:::|...|: ..|   ||:|||..|.::.||||..::.:|:|||:::|
Mouse   484 NKYQLSIHEREDSPQSH---VLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGL 545

  Fly   300 -EIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGM 363
             |.:|......|.:|:..|.|.:.  :|||.|                       .|..|.|:|:
Mouse   546 GERVLGFCQLNLPSGKFPRGFKFD--TDELNF-----------------------PTEKLCFVGL 585

  Fly   364 IATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTA 428
            ::..:|||:.:|.||.:||:||||:|:||...|..|||:|..|||:...::|.:.:..:...|.:
Mouse   586 MSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVS 650

  Fly   429 EV------------VDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAV 481
            :|            .|:.....|:       :::::.:..::|.|.||..|...|.:.|:|.||:
Mouse   651 QVNPREAKACVVHGSDLKDMTSEQ-------LDEILRDHTEIVFARTSPQQKLIIVEGCQRQGAI 708

  Fly   482 VSVIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKA 544
            |:|.|..::|:||::.:.:|:|.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||:
Mouse   709 VAVTGDGVNDSPALKKADIGIAMGISGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKS 772

  Fly   545 LAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VY 608
            :||.|.:||..|..:|.|.:..|||.:..:..|.:....::|||::|.||..|.::|.:.|: ..
Mouse   773 IAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQ 837

  Fly   609 DDFLLNSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQE 673
            .|.|:|.||..:::..:|.|:|...|.||||.:|:.||||..|:.:.:.|.|...:|:.||:|||
Mouse   838 TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTTNDLEDSYGQE 902

  Fly   674 WSSEARRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLL--------SLAVLLLI 730
            |:.|.|:.:|....:....|:.|:|..:|::.||.|.::...|.:|.:|        :||..|..
Mouse   903 WTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSY 967

  Fly   731 CLCVQLCIMDSTVCLR---LEGTNELHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELAT 792
            |       ....|.||   |:.|       :.....|:.:|:...:..|:..:|.:|..|:|..|
Mouse   968 C-------PGMGVALRMYPLKVT-------WWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKET 1018

  Fly   793 MY 794
            .|
Mouse  1019 YY 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	254/845 (30%)
Atp1a2	NP_848492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	254/845 (30%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..231