DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and PMR1

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_011348.1	Gene:	PMR1 / 852709	SGDID:	S000003135	Length:	950	Species:	Saccharomyces cerevisiae

Alignment Length:	700	Identity:	166/700 - (23%)
Similarity:	298/700 - (42%)	Gaps:	129/700 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSKTLSKWSSSN-----------------MGLACTHAISGIGFAVALACGRNTEVGSMTDLCFK- 48
            :|:|:.| ||.|                 ||   |....|.|..:.:..|.||..|::.::...
Yeast   212 TSQTIEK-SSFNDQPNSIVPISERSCIAYMG---TLVKEGHGKGIVVGTGTNTSFGAVFEMMNNI 272

  Fly    49 ERSRSRSQ----KHQKQISYY-MLLVAIVCFILLFLTTGFEHGHI---VYEVNLSLLIGLTPVYL 105
            |:.::..|    |..|.:|.. .:::.::|.:      |...|..   ::::::||.:...|..|
Yeast   273 EKPKTPLQLTMDKLGKDLSLVSFIVIGMICLV------GIIQGRSWLEMFQISVSLAVAAIPEGL 331

  Fly   106 PFILYWGLRRTRKEMGRKQCHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV------DM 164
            |.|:...|......|.:::..||.|.:..|||...||.||..||:|...|.||:::.      .:
Yeast   332 PIIVTVTLALGVLRMAKRKAIVRRLPSVETLGSVNVICSDKTGTLTSNHMTVSKLWCLDSMSNKL 396

  Fly   165 GLLSVDNLDVSAQSPRFI---------ELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALL 220
            .:||:|....:..|...:         |.:....|||       |....:......||..|:|||
Yeast   397 NVLSLDKNKKTKNSNGNLKNYLTEDVRETLTIGNLCN-------NASFSQEHAIFLGNPTDVALL 454

  Fly   221 -KFGLMILPSIDLLRHDHEKVANKHYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCST 284
             :.....:|.|   |:..:||....:||:.|:..| ......|.  |..:.:||..|.::...::
Yeast   455 EQLANFEMPDI---RNTVQKVQELPFNSKRKLMAT-KILNPVDN--KCTVYVKGAFERILEYSTS 513

  Fly   285 F----AIRDEELPLDEQLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEY 345
            :    ..:.|:  |.|..:..|...|:.:...|..|..||...|||.         :|.|.....
Yeast   514 YLKSKGKKTEK--LTEAQKATINECANSMASEGLRVFGFAKLTLSDS---------STPLTEDLI 567

  Fly   346 KYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILP 410
            |          .|.|.|:|...:|||..:..|:::....|:.:|::|......|..:|..:|| |
Yeast   568 K----------DLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGDSENTAVNIAKQIGI-P 621

  Fly   411 APSDTFQAVNLKRMPPTAEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADAC 475
            .            :.|...|:. ....||....|..:    :::..::...||...:|: |..|.
Yeast   622 V------------IDPKLSVLS-GDKLDEMSDDQLAN----VIDHVNIFARATPEHKLN-IVRAL 668

  Fly   476 RRLGAVVSVIGGTLHDTPAMRSSHVGVA--KYGSAVMCEASADLILLDTSFATLVSVVGDSRLLF 538
            |:.|.||::.|..::|.||::.|.:||:  :.|:.|..||| |::|.|..|:|:::.:.:.:.:|
Yeast   669 RKRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEAS-DMVLTDDDFSTILTAIEEGKGIF 732

  Fly   539 ENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQ 603
            .|::..|.:.|:|::..:.:........:|..::.|..|.:..|::..||.:|..||.:..:|.:
Yeast   733 NNIQNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKK 797

  Fly   604 MPKVYDDFLLN----SRLFFVSH-ILVGTIEAAAVFMTYFVF---MADKG 645
            .|:...|.:|.    .||...:. |:|||:         ::|   ||:.|
Yeast   798 PPRKRTDKILTHDVMKRLLTTAACIIVGTV---------YIFVKEMAEDG 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	29/144 (20%)
		Cation_ATPase	190..284	CDD:289987	24/94 (26%)
		Cation_ATPase_C	582..777	CDD:295563	19/71 (27%)
PMR1	NP_011348.1	ATPase-IIA2_Ca	35..940	CDD:130585	165/699 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910