DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and ECA3

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_563860.1	Gene:	ECA3 / 837550	AraportID:	AT1G10130	Length:	998	Species:	Arabidopsis thaliana

Alignment Length:	875	Identity:	207/875 - (23%)
Similarity:	363/875 - (41%)	Gaps:	197/875 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTD--LCFKERSRSRSQKHQKQISYYMLLVAIVCFI 75
            |:..:.|..::|.|.||.:..|.||.:||:.|  |...:.:....:|..:..|:...::|.:| :
plant   203 NILFSGTDVVAGRGRAVVIGVGSNTAMGSIHDSMLQTDDEATPLKKKLDEFGSFLAKVIAGIC-V 266

  Fly    76 LLFLTT----------GFEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            |:::..          ||..|.|.| ::.::|.:...|..||.::...|....|:|.|....||:
plant   267 LVWVVNIGHFSDPSHGGFFKGAIHYFKIAVALAVAAIPEGLPAVVTTCLALGTKKMARLNAIVRS 331

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEI---------------------FVDMGLLSVDN-- 171
            |.:..|||.:|||.||..||:|...|.||:|                     :...|.:...|
plant   332 LPSVETLGCTTVICSDKTGTLTTNMMSVSKICVVQSAEHGPMINEFTVSGTTYAPEGTVFDSNGM 396

  Fly   172 -LDVSAQSPRFIELIRASVLCNDAVICPGNIGVPKMQKDMY---GNILDIALL----KFGLMILP 228
             ||:.||||....|...|.||||:::      .....||.|   |...::||.    |.|   ||
plant   397 QLDLPAQSPCLHHLAMCSSLCNDSIL------QYNPDKDSYEKIGESTEVALRVLAEKVG---LP 452

  Fly   229 SID--------LLRHDHEKVANKHYNSEDKVQVTVHRTRDAD------GHLKL-VLLMKGHCEVV 278
            ..|        |.:|:.....|.::.::.|....:..|||..      .|.:: |:..||..|.:
plant   453 GFDSMPSALNMLSKHERASYCNHYWENQFKKVYVLEFTRDRKMMSVLCSHKQMDVMFSKGAPESI 517

  Fly   279 IRRCSTFAIRDEELPLDEQLQEIILSLADG----LLEAGRHVRAFAYKELSDELEFR----RFSQ 335
            |.||:.                 ||...||    |..|||......:....|| ..|    .|..
plant   518 IARCNK-----------------ILCNGDGSVVPLTAAGRAELESRFYSFGDE-TLRCLALAFKT 564

  Fly   336 VNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAK 400
            |..|.:...|...:       .|.|:|::...:|||..:..|:..|..|||::||||......|:
plant   565 VPHGQQTISYDNEN-------DLTFIGLVGMLDPPREEVRDAMLACMTAGIRVIVVTGDNKSTAE 622

  Fly   401 ALAVDVGILPAPSD----TFQAVNLKRMPPTAEVV---DMSQYADEKPQHQRRHIEQLILNQQDL 458
            :|...:|......|    ::.|...:|:|...:.:   .|:.::..:|.|:|..:|
plant   623 SLCRKIGAFDNLVDFSGMSYTASEFERLPAVQQTLALRRMTLFSRVEPSHKRMLVE--------- 678

  Fly   459 VCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTS 523
                           |.::...||::.|..::|.||::.:.:|:|......:.::::|::|.|.:
plant   679 ---------------ALQKQNEVVAMTGDGVNDAPALKKADIGIAMGSGTAVAKSASDMVLADDN 728

  Fly   524 FATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDEL--ILAFLVNLV 586
            ||::|:.|.:.|.::.|.|:.:.|.:::||..::......:||||      |.|  :....||||
plant   729 FASIVAAVAEGRAIYNNTKQFIRYMISSNIGEVVCIFVAAVLGIP------DTLAPVQLLWVNLV 787

  Fly   587 ----PALTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVGT---IEAAAVFMTYFVFMADK 644
                ||..:.:...:.::|...|:...:.::...||| .::::|.   :...|.|:.:||: :|.
plant   788 TDGLPATAIGFNKQDSDVMKAKPRKVGEAVVTGWLFF-RYLVIGVYVGLATVAGFIWWFVY-SDG 850

  Fly   645 GFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQ--LECQV------SSLCLMSLAVMQCTN 701
            |  |:                :|.|....:.:.|.|:  ..|.:      |::.:..|.|::..|
plant   851 G--PK----------------LTYSELMNFETCALRETTYPCSIFEDRHPSTVAMTVLVVVEMFN 897

  Fly   702 L---------VLTKTGRANLLAHGFRNWLLSLAVLLLICLCVQLCIMDSTVCLRLEGTNELHFGH 757
            .         :|..|.|:||       ||:...:|.::...:.|.:....|...:...:...:..
plant   898 ALNNLSENQSLLVITPRSNL-------WLVGSIILTMLLHVLILYVHPLAVLFSVTPLSWAEWTA 955

  Fly   758 FLLTNCPFMI---LLVFI--ETTRRYFIRL 782
            .|..:.|.:|   ||.|:  .|..|:..||
plant   956 VLYLSFPVIIIDELLKFLSRNTGMRFRFRL 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	34/131 (26%)
		Cation_ATPase	190..284	CDD:289987	30/115 (26%)
		Cation_ATPase_C	582..777	CDD:295563	45/223 (20%)
ECA3	NP_563860.1	Cation_ATPase_N	4..72	CDD:279080
		ATPase-IIA1_Ca	53..975	CDD:273452	203/863 (24%)
		E1-E2_ATPase	92..336	CDD:278548	34/133 (26%)
		Cation_ATPase	416..524	CDD:289987	30/133 (23%)
		COG4087	<604..>707	CDD:226572	26/126 (21%)
		Cation_ATPase_C	776..973	CDD:279079	44/223 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010