Protein Alignment CG45062 and ATP13A3

DIOPT Version :9

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001354478.1
• Gene: ATP13A3 / 79572
• HGNCID: 24113
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 730
• Identity: 140/730 - (19%)
• Similarity: 259/730 - (35%)
• Gaps: 223/730 - (30%)

  Fly    28 AVALACGRNTEVGSMTDLCFKERSRSRSQKHQKQISY------YMLLVAIVC-----FILLFLTT 81
            |:.:..|.:|..|.:.          ||..:.|...:      |:.|:.:|.     ||...:.:
Human   378 AIVVRTGFSTSKGQLV----------RSILYPKPTDFKLYRDAYLFLLCLVAVAGIGFIYTIINS 432

  Fly    82 ---GFEHGHIVYEVNLSLLIGLTPVYLPFILYWGL---RRTRKEMGRKQCHVRNLRATCTLGLST 140
               ..:.|.|:.| :|.::....|..||..:..|:   :|..|::|......:.:.....|.|
Human   433 ILNEVQVGVIIIE-SLDIITITVPPALPAAMTAGIVYAQRRLKKIGIFCISPQRINICGQLNL-- 494

  Fly   141 VIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLDV----SAQSPRFIELIRASVLCNDAVI----- 196
             :..|..||:|:                 |.||:    ..::.||  |.....:||:.::
Human   495 -VCFDKTGTLTE-----------------DGLDLWGIQRVENARF--LSPEENVCNEMLVKSQFV 539

  Fly   197 -CPGNI-GVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSEDKVQVTVHR-- 257
             |.... .:.|::..:.|:.||:.:.:....||          |:...:.....:::..||.|
Human   540 ACMATCHSLTKIEGVLSGDPLDLKMFEAIGWIL----------EEATEEETALHNRIMPTVVRPP 594

  Fly   258 -----------TRDAD--------------------------------GHLKLVLLMKGHCEVVI 279
                       .::.:                                |..|:...|||..|.:.
Human   595 KQLLPESTPAGNQEMELFELPATYEIGIVRQFPFSSALQRMSVVARVLGDRKMDAYMKGAPEAIA 659

  Fly   280 RRCSTFAIRDEELPLDEQLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGE 344
            ..|     :.|.:|:|.|      ::.:...:.|..|.|.|:::|..:|.:.:...::
Human   660 GLC-----KPETVPVDFQ------NVLEDFTKQGFRVIALAHRKLESKLTWHKVQNIS------- 706

  Fly   345 YKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGIL 409
               ||  |::. ::.|:|:|...|..:...|..::....|.|:.::||......|.::|.|.|::
Human   707 ---RD--AIEN-NMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDSMLTAVSVARDCGMI 765

  Fly   410 PAPSDTFQAVNLKRMPP-TAEVVDMS-QYAD-------------------------EKPQHQRRH 447
             .|.|  :.:..:.:|| ..:|..:: .|||                         |..|..|.|
Human   766 -LPQD--KVIIAEALPPKDGKVAKINWHYADSLTQCSHPSAIDPEAIPVKLVHDSLEDLQMTRYH 827

  Fly   448 IE------QLILNQ-QDL---------VCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMR 496
            ..      .:||.. |||         |.|..:.||...:.:|.:.:...|.:.|...:|..|::
Human   828 FAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLIEALQNVDYFVGMCGDGANDCGALK 892

  Fly   497 SSHVGVAKYGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLF 561
            .:|.|::      :.|..|.:....||....:|.|       .||.:.....|.|:.|   |:.|
Human   893 RAHGGIS------LSELEASVASPFTSKTPSISCV-------PNLIREGRAALITSFC---VFKF 941

  Fly   562 FFLLGIPLYIHIMDELILAFLVN--------------LVPALTLIYEPPEENLMLQMPKVYDDFL 612
            ..|..|..|..:  .|:.:.|.|              ||...|:...|..:.|:.|.|   ...|
Human   942 MALYSIIQYFSV--TLLYSILSNLGDFQFLFIDLAIILVVVFTMSLNPAWKELVAQRP---PSGL 1001

  Fly   613 LNSRLFF--VSHILV 625
            ::..|.|  :|.|::
Human  1002 ISGALLFSVLSQIII 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	23/120 (19%)
		Cation_ATPase	190..284	CDD:289987	20/145 (14%)
		Cation_ATPase_C	582..777	CDD:295563	14/60 (23%)
ATP13A3	NP_001354478.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930