Protein Alignment CG45062 and Atp2c2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_081198.1
• Gene: Atp2c2 / 69047
• MGIID: 1916297
• Length: 944
• Species: Mus musculus
• Alignment Length: 689
• Identity: 156/689 - (22%)
• Similarity: 284/689 - (41%)
• Gaps: 143/689 - (20%)

  Fly    12 SNMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFK-----ERSRSRSQKHQKQISYYMLLVAI 71
            ||:....|....|.|..|.:..|..::.|.:    ||     |..::..||...::...:.:.:.
Mouse   241 SNVVFMGTLVQCGKGQGVVIGTGEQSQFGEV----FKMMRAEETPKTPLQKSMDKLGKQLTIFSF 301

  Fly    72 VCFILLFLTTGFEHGH---IVYEVNLSLLIGLTPVYLPFI----LYWGLRRTRKEMGRKQCHVRN 129
            ....||.| .|:..|.   .::.|.:||.:...|..||.:    |..|:.|    |.:|:..|:.
Mouse   302 GIIGLLML-VGWVQGKPFLSMFTVGVSLAVAAIPEGLPIVVMVTLVLGVLR----MAKKRVIVKK 361

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMG------------------------LLSVD 170
            |....|||...||.||..||:|...|..:::....|                        :...|
Mouse   362 LPIVETLGCCNVICSDKTGTLTANEMTATQLVTSDGFHAEVSGVGYSGEGTVCLLPSKEVIKGFD 426

  Fly   171 NLDVSAQSPRFIELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRH 235
            |:.|.       :|:.|..:.|:|||....:    |.:...|.::.:|:    .|.|.||   :.
Mouse   427 NVSVG-------KLVEAGCVANNAVIRKNAV----MGQPTEGALVVLAM----KMNLGSI---KD 473

  Fly   236 DHEKVANKHYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQE 300
            .:.:.....::||.|........:..||  :.:..|||..|.||..||.:......|||..|.:.
Mouse   474 SYVRKKEIPFSSEQKWMAVRCGPKSEDG--EDIYFMKGAFEEVIHHCSMYNNGGIPLPLTPQQKS 536

  Fly   301 IILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIA 365
            ........:...|..|.|.|                 :|.|.|.             |.|||::.
Mouse   537 YCQQEEKKMGSLGLRVLALA-----------------SGPELGR-------------LTFLGLVG 571

  Fly   366 TYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPT--- 427
            ..:|||:.:.:||.....:|:.:.:||....:.|.|:...:|:.   ::..:|::.:.:..|
Mouse   572 IIDPPRAGVKEAVQVLSESGVSVKMVTGDALETALAIGRTIGLC---NEKLKAMSGEEVEGTEQG 633

  Fly   428 ---AEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTL 489
               |.|..:|.:....|:|:.:                        |..|.:..||:|::.|..:
Mouse   634 ALAARVRQVSVFFRTSPKHKVK------------------------IIKALQESGAIVAMTGDGV 674

  Fly   490 HDTPAMRSSHVGVA--KYGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATN 552
            :|:.|::|:.:|:|  :.|:.|..|| |::||:|..|:.::|.|.:.:.:|.|:|..:.:.|:|:
Mouse   675 NDSVALKSADIGIAMGQTGTDVSKEA-ANMILVDDDFSAIMSAVEEGKGIFYNIKNFVRFQLSTS 738

  Fly   553 ICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDFLLNSRL 617
            |..:.:.....:..:|..::.|..|.:..:::..||.:|..||.:.:.:.:.|:...|.:||..|
Mouse   739 IAALSLITLSTVCNLPSPLNAMQILWVNIIMDGPPAQSLGVEPVDRDALRRPPRSVGDTILNRAL 803

  Fly   618 FFVSHILVGTIEAAAVFM--TYFVFM----ADKGFLPRT 650
                  ::..:.:|||.:  |.|:|.    |:....|||
Mouse   804 ------ILRVLMSAAVIIGGTLFIFWREIPANGTSTPRT 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	155/688 (23%)
Atp2c2	NP_081198.1	Interaction with ORAI1. /evidence=ECO:0000250|UniProtKB:O75185	69..93
		P-type_ATPase_SPCA	83..925	CDD:319779	156/689 (23%)