DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and atp1a1a.1

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_571761.1	Gene:	atp1a1a.1 / 64612	ZFINID:	ZDB-GENE-001212-1	Length:	1028	Species:	Danio rerio

Alignment Length:	826	Identity:	250/826 - (30%)
Similarity:	422/826 - (51%)	Gaps:	85/826 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCF-KERSRSRSQKHQKQISYYMLLVAI---VC 73
            |:....|:.:.|....:.:..|..|.:|.:..|.. .|..|:......:...:.:..||:   |.
Zfish   244 NIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGRTPISIEIEHFIHIITGVAVFLGVS 308

  Fly    74 FILLFLTTGFEH--------GHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRNL 130
            |.:|.|..|:..        |.||..|...||..:|..         |..|.|.|.:|.|.|:||
Zfish   309 FFILSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMAKKNCLVKNL 364

  Fly   131 RATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIELIRASV 189
            .|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:      ....|..:..|.|.:.
Zfish   365 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTSFDRSSATWAALARVAG 429

  Fly   190 LCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSEDKVQVT 254
            |||.||.......:|.:::|:.|:..:.||||...:...|:..:|..:.|::...:||.:|.|::
Zfish   430 LCNRAVFLAEQENIPILKRDVAGDASESALLKCIELCCGSVKEMREKYNKISEIPFNSTNKYQLS 494

  Fly   255 VHRTRDADG-HLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIILSLADGLLEAGRHVRA 318
            :|:..:::. ..|.:|:|||..|.::.|||:..|:.:|.|||:::::...:....|...|..|..
Zfish   495 IHQNPNSNNTESKHLLVMKGAPERILDRCSSILIQGKEQPLDDEMKDAFQNAYLELGGLGERVLG 559

  Fly   319 FAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRA 383
            |.:..|.|| :|....|.:|          :.:...|.:|.|:|:::..:|||:.:|.||.:||:
Zfish   560 FCHFNLPDE-QFPEDFQFDT----------EEVNFPTENLCFIGLMSMIDPPRAAVPDAVGKCRS 613

  Fly   384 AGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAE---------VVDMSQYADE 439
            ||||:|:||...|..|||:|..|||:...::|.:.:..:...|..|         |:......|.
Zfish   614 AGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPINEVNPRDAKACVIHGGDLKDL 678

  Fly   440 KPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAK 504
            .|:    .::.::.:..::|.|.||..|...|.:.|:|.||:|:|.|..::|:||::.:.:|||.
Zfish   679 SPE----QLDDVLKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM 739

  Fly   505 --YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGI 567
              .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::||.|.:||..|..:|.|.:..|
Zfish   740 GIAGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANI 803

  Fly   568 PLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLLNSRLFFVSHILVGTIEAA 631
            ||.:..:..|.:....::|||::|.||..|.::|.:.|: ...|.|:|.||..:::..:|.|:|.
Zfish   804 PLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPKTDKLVNERLISIAYGQIGMIQAL 868

  Fly   632 AVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVSSLCLMSLAV 696
            |.|.||||.:|:.||||.:|:.:.:.|.|..::|:.||:||:|:.|.|:.:|....:....|:.:
Zfish   869 AGFFTYFVILAENGFLPSSLLGIRVFWDDKYVNDLEDSYGQQWTYEQRKIVEFTCHTAFFTSIVI 933

  Fly   697 MQCTNLVLTKTGRANLLAHGFRNWLL--------SLAVLLLICLCVQLCIMDSTVCLRLEGTNEL 753
            :|..:|::.||.|.::...|.:|.:|        :||..|..|..     ||  |.||:
Zfish   934 VQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPG-----MD--VALRM------ 985

  Fly   754 HFGHFLLTN---C--PFMILLVFIETTRRYFIRLFPDSWLELATMY 794
               :.|..|   |  |:.:|:...:..|:..||..|..|:|..|.|
Zfish   986 ---YPLKPNWWFCAFPYSLLIFIYDEIRKLIIRRSPGGWVERETYY 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	32/130 (25%)
		Cation_ATPase	190..284	CDD:289987	28/94 (30%)
		Cation_ATPase_C	582..777	CDD:295563	63/208 (30%)
atp1a1a.1	NP_571761.1	ATPase-IIC_X-K	38..1028	CDD:273445	249/824 (30%)
		Cation_ATPase_N	43..117	CDD:214842
		E1-E2_ATPase	137..368	CDD:278548	33/132 (25%)
		Cation_ATPase	430..526	CDD:289987	29/95 (31%)
		COG4087	611..757	CDD:226572	50/150 (33%)
		Cation_ATPase_C	804..1013	CDD:279079	67/224 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910