DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and JYalpha

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	255/836 - (30%)
Similarity:	417/836 - (49%)	Gaps:	106/836 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SSNMGLACTHAISGIGFAVALACGRNTEVGSMTDLC--FKERSRSRSQKHQKQISYYMLLVAI-- 71
            :.|:....|:.:.|....|.:|.|.:|.:|.:.:|.  ..:.....|::.|..|.:..:...|
  Fly   228 TKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDDVQSPISREIQLFIRFITIFAIILG 292

  Fly    72 VCFILLFLTTGFEH--------GHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVR 128
            :.|..:.||.|:|.        |.||..|...||:.:|..         |..|.|.|..|.|.|:
  Fly   293 LSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVTVTVC---------LTLTAKRMASKNCLVK 348

  Fly   129 NLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIELIRA 187
            ||.|..|||.::.|.||..||:|:.||.|:.::.|..::..|..:      ...:...|..|...
  Fly   349 NLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTESFRGSHFKIEDKSFNALFMC 413

  Fly   188 SVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSEDKVQ 252
            :.|||.|....|...:|..:||:.||..:.|||||...|...|...|..|.|:....:||.:|.|
  Fly   414 AALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGAFRQKHIKLTEIPFNSTEKYQ 478

  Fly   253 VTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQ--------------EIIL 303
            |:||....:||:  .::.|||..|.::.||||..|:...:.|...|:              |.:|
  Fly   479 VSVHEFNSSDGY--FIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEAYLEMGGMGERVL 541

  Fly   304 SLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYN 368
            ..||.||...::  ..:|:..:|...|        .||               :|||||:|:..:
  Fly   542 GFADLLLPMSKY--PISYEFSADPPNF--------PLE---------------NLRFLGLISLID 581

  Fly   369 PPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPS---------------DTFQA 418
            |||:.:|.||.:||:||:::|:||...|..|||:|..|||:..|:               |:.||
  Fly   582 PPRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIITTPTAEDIAKQRGVTVLDIDSRQA 646

  Fly   419 VNLKRMPPTAEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVS 483
                    ||.||    :..|..:.:...::.:|....::|.|.||..|...|.:||:|.|.:|:
  Fly   647 --------TAIVV----HGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVA 699

  Fly   484 VIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALA 546
            |.|..::|:||::.:.:|||.  .||.|..:| ||:||||.:||::|..:.:.|::|:||||::|
  Fly   700 VTGDGVNDSPALKRADIGVAMGISGSDVSKQA-ADMILLDDNFASIVVGIEEGRIIFDNLKKSIA 763

  Fly   547 YCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDD 610
            |.|.:|:..|:.:|||.:..|||.:..:..|.:....:::||::|.||..|.::|.:||: .::|
  Fly   764 YTLTSNLPEIVPFLFFVIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFED 828

  Fly   611 FLLNSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWS 675
            .|:|.:|..::::.:|.|:..|.|.|:|..||:.||.|..|..:...|....::|:.|.:||||:
  Fly   829 RLVNKKLILMAYLQIGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWT 893

  Fly   676 SEARRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLLSLAVLLLICLCVQLCIMD 740
            ...|:.||....:...:|:.|.|..:|::.||.|.::|..|..|.:|:.|::|...:...||.:.
  Fly   894 YRERKVLEYTAGTGFFVSIVVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVP 958

  Fly   741 STVCLRLEGTNELHFGHFL--LTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
            .     .|.|..::...|:  :...||.:|:.|.:.:||:.||..|..|:|..|.|
  Fly   959 V-----FEKTLRMYSIKFIWWIYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	34/130 (26%)
		Cation_ATPase	190..284	CDD:289987	35/93 (38%)
		Cation_ATPase_C	582..777	CDD:295563	57/197 (29%)
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	254/834 (30%)
		Cation_ATPase_N	29..102	CDD:214842
		E1-E2_ATPase	123..354	CDD:278548	35/134 (26%)
		Cation_ATPase	416..509	CDD:289987	36/94 (38%)
		COG4087	<673..738	CDD:226572	27/65 (42%)
		Cation_ATPase_C	785..994	CDD:279079	62/213 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438579
Domainoid	1	1.000	67	1.000	Domainoid score	I532
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I96
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.900