DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and atp2a3

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_697108.5	Gene:	atp2a3 / 568671	ZFINID:	ZDB-GENE-060531-103	Length:	1005	Species:	Danio rerio

Alignment Length:	849	Identity:	179/849 - (21%)
Similarity:	355/849 - (41%)	Gaps:	148/849 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSM-TDLCFKERSRSRSQKHQKQISYYM-LLVAIVCFI 75
            ||..:.|:..:|....|.::.|.:||:|.: ..:...|:.::..|:...:....: .:::::|..
Zfish   206 NMLFSGTNIAAGRAIGVVVSTGVSTEIGKIRNQMAATEQEKTPLQQKLDEFGQQLSKVISLICIA 270

  Fly    76 LLFLTTG----------FEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            :..:..|          :..|.|.| ::.::|.:...|..||.::...|....:.|.:|...||:
Zfish   271 VWVINIGHFADPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV----DMGLLSVDNLDVSAQ--SPR-------- 180
            |.:..|||.::||.||..||:|..:|.|..:||    |....|:....:|..  :|.
Zfish   336 LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVNKADDSSCSLHEFTISGSTYAPEGEVLKADK 400

  Fly   181 ---------FIELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIAL---------LKFGLMIL 227
                     .:||.....||||:.:   :....|...:..|...:.||         .|..|..|
Zfish   401 QVQCGDYDGLVELATICSLCNDSSL---DYNEAKGVYEKVGEATETALTTLVEKMNVFKTDLSGL 462

  Fly   228 PSID-------LLRHDHEKVANKHYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTF 285
            ..:|       ::|...:|.....: |.|:..::|:.|.:.. :.:..:.:||..|.||.||...
Zfish   463 SKVDRAAACNLIIRQLMQKKFTLEF-SRDRKSMSVYCTPNGT-NSQSKMFVKGAPEGVIDRCQFV 525

  Fly   286 AIRDEELPLDEQLQEIILS-LADGLLEAGRH-VRAFAYKELSDELEFRRFSQVNTGLEGGEYKYR 348
            .:..|..||...::|.::| :.|  ...||. :|..|...........:....|.|      |:.
Zfish   526 RVGKERFPLTMAVKEELMSTIRD--WGTGRDTLRCLALATRDSPPAVDKMDLENAG------KFA 582

  Fly   349 DYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPS 413
            :|.:    ||.|:|.:...:|||..:..::..|..|||::|::|......|.|:...:||.....
Zfish   583 EYES----SLTFVGCVGMLDPPRKEVIGSIKLCNKAGIRVIMITGDNKGTAVAICRRIGIFSENE 643

  Fly   414 D----TFQAVNLKRMPPTA--EVVDMSQ-YADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWI 471
            |    .:.......:.|.|  |.|..:: :|..:|.|:.:           :|....|.|:
Zfish   644 DVEGRAYTGREFDDLAPEAQREAVKRARCFARVEPAHKSK-----------IVAYLQSFDE---- 693

  Fly   472 ADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTSFATLVSVVGDSRL 536
                     :.::.|..::|.||::.:.:|:|......:.:::::::|.|.:|:|:|:.|.:.|.
Zfish   694 ---------ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASEMVLSDDNFSTIVAAVEEGRA 749

  Fly   537 LFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFL--VNLV----PALTLIYEP 595
            ::.|:|:.:.|.:::|:..::......:||:|      :.||...|  ||||    ||..|.:.|
Zfish   750 IYNNMKQFIRYLISSNVGEVVCIFLTAILGLP------EALIPVQLLWVNLVTDGLPATALGFNP 808

  Fly   596 PEENLMLQMPKVYDDFLLNSRLFF-----VSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALN 655
            |:.::|.:.|:...:.|::..|||     ..::.:||:.||    |::....:.|  |:  |:..
Zfish   809 PDLDIMDKPPRNPKEPLISGWLFFRYLAIGGYVGLGTVSAA----TWWYLFDEDG--PQ--VSFY 865

  Fly   656 IAWHDDMLDDITDSFGQEWSSEARRQLECQV------SSLCLMSLAVMQCTNLVLTKTGRANLL- 713
            ...|.....:....|         ..:.|:|      :::.|..|..::..|.:.:.:...:||
Zfish   866 QLRHFMQCTEENPMF---------EGINCEVFESRYPTTMALSVLVTIEMFNALNSLSENQSLLR 921

  Fly   714 -AHGFRNWLLSLAVLLLICLCVQLCIMDSTVCLRLEGTNELHFGHFLLTNCPFMILLVFIETTRR 777
             ......|||.   .:::.|.:...|:.......:.....|||..:::. ....|.::.::...:
Zfish   922 MPPWVNIWLLG---AIILSLSLHFLILHVEPLPLIFQVTPLHFSQWIIV-FKISIPVILLDEALK 982

  Fly   778 YFIR 781
            |..|
Zfish   983 YISR 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	26/131 (20%)
		Cation_ATPase	190..284	CDD:289987	25/109 (23%)
		Cation_ATPase_C	582..777	CDD:295563	42/213 (20%)
atp2a3	XP_697108.5	Cation_ATPase_N	4..72	CDD:279080
		ATPase-IIA1_Ca	53..986	CDD:273452	178/847 (21%)
		E1-E2_ATPase	92..340	CDD:278548	26/133 (20%)
		Cation_ATPase	419..525	CDD:289987	25/110 (23%)
		HAD	<601..709	CDD:289480	26/131 (20%)
		Cation_ATPase_C	781..984	CDD:279079	45/229 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010