Protein Alignment CG45062 and atp13a2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001073506.1
• Gene: atp13a2 / 568666
• ZFINID: ZDB-GENE-061215-126
• Length: 1170
• Species: Danio rerio
• Alignment Length: 771
• Identity: 144/771 - (18%)
• Similarity: 259/771 - (33%)
• Gaps: 271/771 - (35%)

  Fly   137 GLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDN--LDVSAQSPRFIE---LIRASVLCNDAVI 196
            |..::...|..||:|:..:.|      .|::.|..  .......|.|:.   ::.|...|:...:
Zfish   484 GKISLFCFDKTGTLTEEGLDV------WGVMEVTGGVFGELVPDPLFLPPGLMLSALASCHSVAL 542

  Fly   197 CPGN-IGVP---KM-----------QKDM-----YGNILDIALLKFGLMILPSIDLLRHDH---E 238
            ..|. :|.|   ||           :.||     :|....:|:::     .|:.:||...:   :
Zfish   543 LGGQALGDPLELKMIESTGWELTEPENDMGHDSEFGGHRVLAVMR-----PPASELLTEGNSVSQ 602

  Fly   239 KVA-NKHYNSEDKVQ----VTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELP--LDE 296
            .|| .:.:.....:|    |||.....:.     |..:||..|:|...|     ..|.:|  ...
Zfish   603 PVAIVRRFPFSSSLQRMSVVTVGPAEPSP-----VAFIKGAPEMVASFC-----HKESVPSHFSH 657

  Fly   297 QLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFL 361
            .|:|        ....|..|...|||.|:.|.:.....:|.  :|.|              :.||
Zfish   658 TLRE--------YASQGFRVLGLAYKHLAKETDLSTVERVE--VEKG--------------MNFL 698

  Fly   362 GMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPP 426
            |::...|..:....:.:.....|.::.::||......|..:|...|::|...   :.:.:...||
Zfish   699 GLLVMKNQVKPESAEVIQTLTLAQLRPVMVTGDNILTAVNVARVCGMVPLHE---KVIFVHASPP 760

  Fly   427 TA---------------------EVVDM---SQY------------------ADEKPQHQRRHIE 449
            ||                     :.:|:   .||                  .|..|:    ::.
Zfish   761 TAGSQASLQFHEGEGATATINTQQTIDIPVQGQYQSAVGYHLAINGMSFAALCDHFPE----YLP 821

  Fly   450 QLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEAS 514
            ::::  :..:.|..:.:|...:..|.::|...|.:.|...:|..|:|::.|||:      :.:|.
Zfish   822 KVLM--RGTIYARMTPEQKTQLVKALQKLNYRVGMCGDGANDCGALRAADVGVS------LSDAE 878

  Fly   515 ADLILLDTSFATLVSVV------GDSRL-----------LFENLKKALAYCLATNICNI--LVYL 560
            |.:....||.:..:|.|      |...|           |:..::.|....|.|...|:  |.:|
Zfish   879 ASVASPFTSKSDNISCVPLLIKEGRCSLVTSFSLFKYMALYSLIQFASVLILYTEKTNLGDLQFL 943

  Fly   561 FFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILV 625
            ||             :|:|.    .|.|:.:....|..:|..|.|
Zfish   944 FF-------------DLVLV----TVLAILMGRGGPSNDLHPQRP-------------------- 971

  Fly   626 GTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVSSLC 690
                 ||..::          ||   |..::..|..:|                  :..|||.|
Zfish   972 -----AASLLS----------LP---VLASLLMHTVLL------------------ILAQVSGL- 999

  Fly   691 LMSLAVMQCTNLVLTKTGRANL---------LAHGFRNWLLSLAV-------------LLLICLC 733
            |::::......|..|:||.|||         ...||:..::|:.:             :|.:|..
Zfish  1000 LITMSQDWYVPLNSTRTGAANLPNMEDTSVFAVSGFQYIIMSVVITKGFPYKKPLYHNVLFVCAL 1064

  Fly   734 VQLCIMDSTVCLRLEGTNELHFGHFL---------LTNCPFMILLVFIETTRRYFI 780
            |.|..:.|.:.|         |.|.:         :|:..:.:|||.| ....:||
Zfish  1065 VFLFALMSWLVL---------FRHTIIHRVLSLYDITDMSYKLLLVAI-AALNFFI 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	144/771 (19%)
atp13a2	NP_001073506.1	P5-ATPase	35..153	CDD:463565
		P-type_ATPase_cation	185..1025	CDD:319842	126/674 (19%)