DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and atp2b3b

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_021325490.1	Gene:	atp2b3b / 558525	ZFINID:	ZDB-GENE-080409-2	Length:	1297	Species:	Danio rerio

Alignment Length:	757	Identity:	173/757 - (22%)
Similarity:	310/757 - (40%)	Gaps:	185/757 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MGLACTHAISGIGFAVALACGRNTEVGSMTDLC-------------------------------- 46
            |.|:.||.:.|.|..:..|.|.|::.|.:..|.
Zfish   267 MLLSGTHVMEGSGRMLVTAVGVNSQSGIIFTLLGAGEGEEEKKEKKGKQPEAAVETNQNKAKKQD 331

  Fly    47 -------------------FKERSRSRSQKHQKQI---------------SYYMLLVAIVCFILL 77
                               .:|:.::...|.:|.:               ...|..:.::..:|.
Zfish   332 GAVAMEMQPLKSAEGGEVEEREKKKANVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLY 396

  Fly    78 FLTTGFEHGHIV----------------YEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCH 126
            |:...|..|::.                :.:.:::|:...|..||..:...|..:.|:|.:....
Zfish   397 FVIDTFVVGNMTWLPECTPIYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL 461

  Fly   127 VRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV-DMGLLSVDNLDVSAQSPRFIELIRASVL 190
            ||:|.|..|:|.:|.|.||..||:|..||.|.:.:: |.....:.  |.|..||..:|:|..::.
Zfish   462 VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYINDQHFREIP--DPSQISPNTLEMIVNAIS 524

  Fly   191 CNDAV---ICPGNI--GVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANK------- 243
            .|.|.   |.|.::  |:||    ..||..:..||.|      .:||.| |:..|..:
Zfish   525 INCAYTSKIMPPDVEGGLPK----QVGNKTECGLLGF------LLDLKR-DYAPVREQIPEEKLY 578

  Fly   244 ---HYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCST----------FAIRDEELPLD 295
               .:||..|...||  .:..||..:  |..||..|:|:::||:          |..||.    |
Zfish   579 KVYTFNSVRKSMSTV--VQMPDGSFR--LYSKGASEIVLKKCSSILGTNGEARNFRPRDR----D 635

  Fly   296 EQLQEIILSLA-DGLLEAGRHVRAFAYKEL--SDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYS 357
            |.::::|..:| :||     ......|::|  ..|.|:...:::.|                  .
Zfish   636 EMVKKVIEPMACEGL-----RTICIGYRDLPGDPEPEWENEAEIVT------------------D 677

  Fly   358 LRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLK 422
            |..:.::...:|.|..:|.|:.:|:.|||.:.:||......|:|:|...||: .|.|.|..:..|
Zfish   678 LTCIAVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAIASKCGII-QPGDDFLCLEGK 741

  Fly   423 RMPPTAEVVDMS-QYADEKPQHQRRHIEQLILNQQDLVCAATSTDQ---LHWIADAC---RRLGA 480
                     |.: :..:||.:.::..|:: |..:..::..::.||:   :..|.|:.   :|  .
Zfish   742 ---------DFNRRIRNEKGEIEQERIDK-IWPKLRVLARSSPTDKHTLVKGIIDSTVLEQR--Q 794

  Fly   481 VVSVIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKK 543
            ||:|.|...:|.||::.:.||.|.  .|:.|..||| |:||.|.:|:::|..|...|.:::::.|
Zfish   795 VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS-DIILTDDNFSSIVKAVMWGRNVYDSISK 858

  Fly   544 ALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVY 608
            .|.:.|..|:..::|......:.....:..:..|.:..:::...:|.|..|||.|.|:|:.|...
Zfish   859 FLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTEALLLRKPYGR 923

  Fly   609 DDFLLNSRLFFVSHIL-VGTIEAAAVFMTYFV----FMADKG 645
            ::.|::  |..:.:|| .|..:...:|...||    |..|.|
Zfish   924 NNPLIS--LTMMKNILGHGVYQLVIIFTLLFVGEKIFNIDSG 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	29/199 (15%)
		Cation_ATPase	190..284	CDD:289987	30/108 (28%)
		Cation_ATPase_C	582..777	CDD:295563	20/69 (29%)
atp2b3b	XP_021325490.1	E1-E2_ATPase	27..1068	CDD:332568	173/757 (23%)
atp2b3b	XP_021325490.1	ATP_Ca_trans_C	1107..1191	CDD:315156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930