DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and ATP7A

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens

Alignment Length:	661	Identity:	117/661 - (17%)
Similarity:	235/661 - (35%)	Gaps:	213/661 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LACGRNTEVGSMTDL-----CFKERSRSRSQKHQ---KQISYYMLLVAIVCF--ILLFLTTGFEH 85
            |.|.  |.||:.|.|     ..:|...|::...|   |...|::..:..|..  :|:::..||.:
Human   901 LICA--THVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLN 963

  Fly    86 GHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVR----------NLRATCTLGLST 140
            ..||            ..|.|     |..|:   :.|.:..:|          .:...|:|||:|
Human   964 FEIV------------ETYFP-----GYNRS---ISRTETIIRFAFQASITVLCIACPCSLGLAT 1008

  Fly   141 -------------------------------VIVSDLVGTMTKRRMRVSEIFV--DMGLLS---- 168
                                           |:|.|..||:|.....|:::.|  :...:|
Human  1009 PTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKI 1073

  Fly   169 ---VDNLDVSAQSPRFIELIR-------ASVL--CNDAVICPGNIGVPKMQKDMYGNILDIALLK 221
               |...:.:::.|....:.:       ...|  |.|..:.|| .|:.....::.|
Human  1074 LAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPG-CGISCKVTNIEG--------- 1128

  Fly   222 FGLMILPSIDLLRHDHEKVANKHYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFA 286
                      ||..::..:.:.:..:...||:.....:.:                    .|:..
Human  1129 ----------LLHKNNWNIEDNNIKNASLVQIDASNEQSS--------------------TSSSM 1163

  Fly   287 IRDEEL--PLDEQLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRD 349
            |.|.::  .|:.|..::::...:.::..|..:.                :.||..:...|.|.|.
Human  1164 IIDAQISNALNAQQYKVLIGNREWMIRNGLVIN----------------NDVNDFMTEHERKGRT 1212

  Fly   350 --YLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAP 412
              .:|||.   ...|:||..:..:.....|:...::.|::::::|....|.|:::|..|||...
Human  1213 AVLVAVDD---ELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKV- 1273

  Fly   413 SDTFQAVNLKRMPPTAEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRR 477
                                   :|:..|.|:...::||   |::
Human  1274 -----------------------FAEVLPSHKVAKVKQL---QEE-------------------- 1292

  Fly   478 LGAVVSVIGGTLHDTPAMRSSHVGVA-KYGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENL 541
             |..|:::|..::|:||:..::||:| ..|:.|..|| ||::|:......:|:.:..||...:.:
Human  1293 -GKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEA-ADVVLIRNDLLDVVASIDLSRKTVKRI 1355

  Fly   542 KKALAYCLATNICNILVYLFFFL-LGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMP 605
            :....:.|..|:..|.:....|: :|:.|...:....:.|..|::|  |:.::      |.|...
Human  1356 RINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVV--LSSLF------LKLYRK 1412

  Fly   606 KVYDDFLLNSR 616
            ..|:.:.|.:|
Human  1413 PTYESYELPAR 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	24/120 (20%)
		Cation_ATPase	190..284	CDD:289987	11/95 (12%)
		Cation_ATPase_C	582..777	CDD:295563	8/35 (23%)
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..443	CDD:238219
		HMA	492..554	CDD:238219
		HMA	567..630	CDD:238219
		P-type_ATPase_Cu-like	652..1388	CDD:319783	108/616 (18%)
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1487..1488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141071
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930