DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and atp2a1l

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_005156129.1	Gene:	atp2a1l / 494489	ZFINID:	ZDB-GENE-041229-2	Length:	993	Species:	Danio rerio

Alignment Length:	864	Identity:	197/864 - (22%)
Similarity:	374/864 - (43%)	Gaps:	168/864 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTD-LCFKERSRSRSQKHQKQISYYM-LLVAIVCFI 75
            ||..:.|:..:|....||:|.|..||:|.:.| :...|:.::..|:...:....: .:::::|..
Zfish   206 NMLFSGTNIAAGKAVGVAVATGVATEIGKIRDQMAATEQEKTPLQQKLDEFGEQLSKVISLICVA 270

  Fly    76 LLFLTTG----------FEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            :..:..|          :..|.:.| ::.::|.:...|..||.::...|....:.|.:|...||:
Zfish   271 VWMINIGHFNDPVHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV----DMGLLSVDNLDVS--------------- 175
            |.:..|||.::||.||..||:|..:|.|:::||    |...:.:|:.|:|
Zfish   336 LPSVETLGCTSVICSDKTGTLTTNQMCVTKMFVIDRIDGDHVELDSFDISGSKYTPEGEVTKLGA 400

  Fly   176 ----AQSPRFIELIRASVLCND---------------------AVICPGNIGVPKMQ--KDMYGN 213
                :|....:||.....||||                     |:.|.    |.||.  |...||
Zfish   401 KVDCSQYDGLVELATICALCNDSSLDYNETKKIYEKVGEATETALCCL----VEKMNVFKSNVGN 461

  Fly   214 ILDIALLKFGLMILPSIDLLRHDHEKVANKHYN---SEDKVQVTVHRTRDADGHLKLVLLMKGHC 275
            :..:........::          :::..|::.   |.|:..::|:.| ...|.....:.:||..
Zfish   462 LSKVERANACCSVV----------KQLMKKNFTLEFSRDRKSMSVYCT-PVKGDAGSKMFVKGAP 515

  Fly   276 EVVIRRCSTFAIRDEELPLDEQLQEIILSLADGLLE--AGRH-VRAFAYKELSDELEFRRFSQVN 337
            |.||.||:...:....:||...:::.|:::   :.|  .||. :|..|.......|:....:
Zfish   516 EGVIDRCTYVRVGSTRVPLTGAVKDKIMNV---IKEWGTGRDTLRCLALATRDSPLKVEEMN--- 574

  Fly   338 TGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKAL 402
              ||... |:.||   :| .|.|:|.:...:|||..:..:::.||||||::|::|......|.|:
Zfish   575 --LEDST-KFADY---ET-DLTFVGCVGMLDPPRKEVTGSIELCRAAGIRVIMITGDNKGTAVAI 632

  Fly   403 AVDVGILPAPSD-TFQAVNLKRMP--PTAEVVDMSQ----YADEKPQHQRRHIEQLILNQQDLVC 460
            ...:||.....| |.:|...:...  |.:|..:..:    :|..:|.|:.:.:|  .|...|.:.
Zfish   633 CRRIGIFSEDEDVTGKAYTGREFDDLPHSEQSEAVRRACCFARVEPSHKSKIVE--FLQGYDEIT 695

  Fly   461 AATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTSFA 525
            |.|                      |..::|.||::.:.:|:|......:.:::::::|.|.:|:
Zfish   696 AMT----------------------GDGVNDAPALKKAEIGIAMGSGTAVAKSASEMVLADDNFS 738

  Fly   526 TLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFL--VNLV-- 586
            ::|:.|.:.|.::.|:|:.:.|.:::||..::.......||:|      :.||...|  ||||
Zfish   739 SIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVCIFLTAALGLP------EALIPVQLLWVNLVTD 797

  Fly   587 --PALTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVGT-IEAAAVFMTYFVFMADKGFLP 648
              ||..|.:.||:..:|.:.|:...:.|::..||| .::.||. :.||.|....:.|:.|:....
Zfish   798 GLPATALGFNPPDLEIMGKPPRSPKEPLISGWLFF-RYMTVGAYVGAATVAAAAYWFIYDEEGPQ 861

  Fly   649 RTLVALN--IAWHDDMLDDITDSFGQEWSSEARRQLECQVSSLC---LMSLAVM----QCTNLVL 704
            .|...|:  :..|::. :|.|.             :||:|...|   .|:|:|:    .|..|..
Zfish   862 VTYYQLSHFMQCHEEN-EDFTG-------------IECEVFEACPPMTMALSVLVTIEMCNALNS 912

  Fly   705 TKTGRANLLAHGFRN-WLLSLAVLLLICLCVQLCIMD-STVCLRLEGTNELHFGHFLLTNCPFMI 767
            ....::.:....:.| |||| |:.|.:.|...:..:| ..:..||...|...:  |::....|.:
Zfish   913 LSENQSLVRMPPWSNGWLLS-AMTLSMSLHFMIIYVDPMPMIFRLTHLNTEQW--FVVLKLSFPV 974

  Fly   768 LLVFIETTRRYFIRLFPDS 786
            :|  |:...::..|.:.|:
Zfish   975 IL--IDEMLKFLARNYVDA 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	28/131 (21%)
		Cation_ATPase	190..284	CDD:289987	25/119 (21%)
		Cation_ATPase_C	582..777	CDD:295563	53/212 (25%)
atp2a1l	XP_005156129.1	Cation_ATPase_N	4..72	CDD:279080
		ATPase-IIA1_Ca	53..986	CDD:273452	195/857 (23%)
		E1-E2_ATPase	93..340	CDD:278548	28/133 (21%)
		Cation_ATPase	419..525	CDD:289987	25/120 (21%)
		HAD	<608..709	CDD:289480	29/124 (23%)
		Cation_ATPase_C	781..984	CDD:279079	56/228 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573931
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940